Evidence map›Paper›PMID 35641227›Full record

ArticleeNeuro

A Computational Biomarker of Photosensitive Epilepsy from Interictal EEG.

Marinho A Lopes, Sanchita Bhatia, Glen Brimble, Jiaxiang Zhang, Khalid Hamandi

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Marinho A LopesCardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff CF24 4HQ, United Kingdom m.lopes@exeter.ac.uk.ORCID https://orcid.org/0000-0002-5764-2261
Sanchita BhatiaCardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff CF24 4HQ, United Kingdom.
Glen BrimbleDepartment of Clinical Neurophysiology, University Hospital of Wales, Cardiff CF14 4XW, United Kingdom.
Jiaxiang ZhangCardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff CF24 4HQ, United Kingdom.ORCID https://orcid.org/0000-0002-4758-0394
Khalid HamandiCardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff CF24 4HQ, United Kingdom.
Cardiff University · GBUniversity Hospital of Wales · GB

Funding

Medical Research Council MR/K005464/1Wellcome TrustWellcome Trust 104943/Z/14/ZWellcome Trust 204824/Z/16/Z
6 · The paper itself

Abstract

People with photosensitive epilepsy (PSE) are prone to seizures elicited by visual stimuli. The possibility of inducing epileptiform activity in a reliable way makes PSE a useful model to understand epilepsy, with potential applications for the development of new diagnostic methods and new treatments for epilepsy. A relationship has been demonstrated between PSE and both occipital and more widespread cortical hyperexcitability using various types of stimulation. Here we aimed to test whether hyperexcitability could be inferred from resting interictal electroencephalographic (EEG) data without stimulation. We considered a cohort of 46 individuals with idiopathic generalized epilepsy who underwent EEG during intermittent photic stimulation: 26 had a photoparoxysmal response (PPR), the PPR group, and 20 did not, the non-PPR group. For each individual, we computed functional networks from the resting EEG data before stimulation. We then placed a computer model of ictogenicity into the networks and simulated the propensity of the network to generate seizures

Indexed as

Epilepsy, GeneralizedEpilepsy, ReflexBiomarkersElectroencephalographyHumansPhotic StimulationSeizuresBiomarkersfunctional networkhyperexcitabilityinterictal EEGmathematical modelphotosensitive epilepsy

Identifiers

PMID35641227
PMCPMC9215691
OpenAlexW4282918527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.