Evidence map›Paper›PMID 35641226›Full record

ArticleeNeuro

Recording Synaptic Transmission from Auditory Mixed Synapses on the Mauthner Cells of Developing Zebrafish.

Fabio A Echeverry, Sundas Ijaz, Alberto E Pereda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fabio A EcheverryDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.
Sundas IjazDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.
Alberto E PeredaDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461 alberto.pereda@einsteinmed.edu.ORCID https://orcid.org/0000-0002-4200-4080

Funding

Plasticity of Electrical SynapsesR01DC011099 · NIDCD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Alberto E Pereda · 2010 to 2026
$7.0M
Transgenic tools for revealing the contributions of electrical synapses to neural circuitsRF1MH120016 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MILLER, ADAM C, O'BRIEN, JOHN · 2020 to 2020
$3.1M
Generation of transgenic zebrafish to study electrical synaptic transmissionR21NS085772 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI PEREDA, ALBERTO E · 2013 to 2014
$469k
NIDCD NIH HHS R01 DC011099NIMH NIH HHS RF1 MH120016NINDS NIH HHS R21 NS085772
6 · The paper itself

Abstract

The Mauthner cells are a pair of large reticulospinal neurons that organize sensory-evoked tail flip responses in fishes. An identifiable group of auditory "mixed" (electrical and chemical) synaptic contacts known as "Large Myelinated Club endings" on these cells have provided a valuable model for the study of synaptic transmission in the vertebrate brain. While most of studies were performed in adult fish, we describe here methods that make possible recording synaptic transmission from these contacts in developing zebrafish, a genetically tractable vertebrate species which is uniquely amenable for combining synaptic physiology with live imaging and behavioral analysis.

Indexed as

Synaptic TransmissionZebrafishAnimalsGap JunctionsNeuronsSynapsesauditory afferentconnexinelectrical synapsegap junctionglutamatemixed transmission

Identifiers

PMID35641226
PMCPMC9215698

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.