ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Pupil-Linked Arousal Response Reveals Aberrant Attention Regulation among Children with Autism Spectrum Disorder.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- The relationships between anxiety, psychotic-like experiences and autism: a systematic review.Frontiers in psychology · 2025Pooled it
- Early intervention increases reactive joint attention in autistic preschoolers with arousal regulation as mediator.European child & adolescent psychiatry · 2025Trial
- Atypical Attentional Effort During Visual Search in Autistic Adults: Evidence From Task-Evoked Pupillary Responses.Autism research : official journal of the International Society for Autism Research · 2026Article
- Measuring surprisal in sound sequences.Behavior research methods · 2026Article
- Atypical Predictive Processing Is Associated With Sensory Over-Responsivity in Autism.Autism research : official journal of the International Society for Autism Research · 2026Article
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- Locus coeruleus modulation of neurophysiological sensory selectivity differs in autism and other mental health conditions.Translational psychiatry · 2026Article
- Morphometric Latent Factors in Autism and Their Association with Receptor Profiles and Behavior.bioRxiv : the preprint server for biology · 2025Article
- Linking Connectivity Dynamics to Symptom Severity and Cognitive Abilities in Children with Autism Spectrum Disorder: An FNIRS Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Autonomic Disequilibrium at Rest in Autistic Children and Adults.Applied psychophysiology and biofeedback · 2025Article
- The Locus Coeruleus-Noradrenergic System in the Healthy and Diseased Brain: A Narrative Review.European journal of neurology · 2025Review
- Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study.Molecular autism · 2025Article
- Atypical pupil-linked arousal induced by low-risk probabilistic choices, and intolerance of uncertainty in adults with ASD.Cognitive, affective & behavioral neuroscience · 2025Article
- Sensory-movement underpinnings of lifelong neurodivergence: getting a grip on autism.Frontiers in integrative neuroscience · 2025Article
- Idiosyncratic pupil regulation in autistic children.Autism research : official journal of the International Society for Autism Research · 2024Article
- Strategic stabilization of arousal boosts sustained attention.Current biology : CB · 2024Article
- Idiosyncratic pupil regulation in autistic children.bioRxiv : the preprint server for biology · 2024Article
- Cognitive-Affective Functions of the Cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Altered pupil responses to social and non-social stimuli in Shank3 mutant dogs.Molecular psychiatry · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorder (ASD) is a developmental disorder that is characterized by difficulties with social interaction and interpersonal communication. It has been argued that abnormal attentional function to exogenous stimuli precedes and contributes to the core ASD symptoms. Notably, the locus ceruleus (LC) and its noradrenergic projections throughout the brain modulate attentional function, but the extent to which this locus ceruleus-norepinephrine (LC-NE) system influences attention in individuals with ASD, who frequently exhibit dysregulated alerting and attention orienting, is unknown. We examined dynamic attention control in girls and boys with ASD at rest using the pupil dilation response (PDR) as a noninvasive measure of LC-NE activity. When gender- and age-matched neurotypical participants were passively exposed to an auditory stream, their PDR decreased for recurrent stimuli but remained sensitive to surprising deviant stimuli. In contrast, children with ASD showed less habituation to recurrent stimuli as well as a diminished phasic response to deviants, particularly those containing social information. Their tonic habituation impairment predicts their phasic orienting impairment, and both impairments correlated with the severity of ASD symptom. Because of the fact that these pupil-linked responses are observed when individuals passively listen without any task engagement, our findings imply that the intricate and dynamic attention allocation mechanism, mediated by the subcortical LC-NE system, is impaired in ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.