ArticleAmerican journal of epidemiology2022
Benchmarking Observational Analyses Before Using Them to Address Questions Trials Do Not Answer: An Application to Coronary Thrombus Aspiration.
Article in American journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Concordance between target trial emulation and randomised controlled trials: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2026Pooled it
- Conducting observational analyses with the target trial emulation approach: a methodological systematic review.BMJ open · 2024Pooled it
- Reporting of Observational Studies Explicitly Aiming to Emulate Randomized Trials: A Systematic Review.JAMA network open · 2023Pooled it
- Redesigning cardiovascular medicine around sex differences.Nature medicine · 2026Review
- Best (but oft forgotten) practices: Applying the target trial framework in nutrition research.The American journal of clinical nutrition · 2026Article
- Target Trial Emulation and the TARGET Guideline to Advance Rural and Remote Health Research.The Medical journal of Australia · 2026Article
- Tailored Exercise Strategies and Mortality Among Breast Cancer Survivors.JAMA network open · 2026Article
- Machine learning versus logistic regression for propensity score estimation: a trial emulation benchmarked against the PARADIGM-HF randomized trial.European journal of epidemiology · 2026Article
- Treating Hearing Loss With Hearing Aids for the Prevention of Cognitive Decline and Dementia.Neurology · 2026Observational
- Design and Implementation of Observational Studies Emulating a Target Trial.JAMA network open · 2026Article
- Identifying and avoiding design related biases in observational studies using the target trial framework.BMJ medicine · 2026Article
- Endocrine therapies and mortality risk in postmenopausal women with breast cancer: benchmarking an observational analysis against a randomized trial.American journal of epidemiology · 2025Observational
- Adjusting for selection bias due to missing eligibility criteria in emulated target trials.American journal of epidemiology · 2025Article
- Article
- Improving reporting of observational studies of interventions: The TARGET guideline.PLoS medicine · 2025Article
- Machine Learning Versus Logistic Regression for Propensity Score Estimation: A Benchmark Trial Emulation Against the PARADIGM-HF Randomized Trial.medRxiv : the preprint server for health sciences · 2025Article
- Trastuzumab in early curative breast cancer: A target trial emulation benchmarked against two randomized clinical trials.PLoS medicine · 2025Article
- A Benchmark, Expand, and Calibration (BenchExCal) Trial Emulation Approach for Using Real-World Evidence to Support Indication Expansions: Design and Process for a Planned Empirical Evaluation.Clinical pharmacology and therapeutics · 2025Article
- Article
- The target trial framework in global health research: barriers and opportunities.Journal of global health · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To increase confidence in the use of observational analyses when addressing effectiveness questions beyond those addressed by randomized trials, one can first benchmark the observational analyses against existing trial results. We used Swedish registry data to emulate a target trial similar to the Thrombus Aspiration in ST-Elevation Myocardial Infarction in Scandinavia (TASTE) randomized trial, which found no difference in the risk of death or myocardial infarction by 1 year with or without thrombus aspiration among individuals with ST-elevation myocardial infarction. We benchmarked the emulation against the trial at 1 year and then extended the emulation's follow-up to 3 years and estimated effects in subpopulations underrepresented in the trial. As in the TASTE trial, the observational analysis found no differences in risk of outcomes by 1 year between groups (risk difference = 0.7 (confidence interval, -0.7, 2.0) and -0.2 (confidence interval, -1.3, 1.0) for death and myocardial infarction, respectively), so benchmarking was considered successful. We additionally showed no difference in risk of death or myocardial infarction by 3 years, or within subpopulations by 1 year. Benchmarking against an index trial before using observational analyses to answer questions beyond those the trial could address allowed us to explore whether the observational data can be trusted to deliver valid estimates of treatment effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.