Evidence map›Paper›PMID 35640787›Full record

Trial reportNeuroImage2022

Methylphenidate remediates aberrant brain network dynamics in children with attention-deficit/hyperactivity disorder: A randomized controlled trial.

Yoshifumi Mizuno, Weidong Cai, Kaustubh Supekar, Kai Makita, Shinichiro Takiguchi, Akemi Tomoda, Vinod Menon

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07029425 (Effectiveness of Manual Therapy in the Treatment of Attention Deficit Hyperactivity Disorder), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07029425 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effectiveness of Manual Therapy in the Treatment of Attention Deficit Hyperactivity Disorder

TypeinterventionalSponsorJJ JIMENEZ-REJANORan2025 to 2026Enrolled60ConditionsAttention Deficit Hyperactivity Disorder (ADHD)ArmsProcedure: craniosacral therapy techniques., Placebo Group
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Bayesian dynamical system analysis of the effects of methylphenidate in children with attention-deficit/hyperactivity disorder: a randomized trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Trial
  7. Trial
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Neural basis for individual differences in the attention-enhancing effects of methylphenidate.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yoshifumi MizunoDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA; Research Center for Child Mental Development, University of Fukui, Fukui, 910-1193, Japan; Division of Developmental Higher Brain Functions, United Graduate School of Child Development, University of Fukui, Fukui, 910-1193, Japan; Department of Child and Adolescent Psychological Medicine, University of Fukui Hospital, Fukui, 910-1193, Japan. Electronic address: mizunoy@u-fukui.ac.jp.
Weidong CaiDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94304, USA; Maternal & Child Health Research Institute, Stanford University, Stanford, CA 94304, USA.
Kaustubh SupekarDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94304, USA; Maternal & Child Health Research Institute, Stanford University, Stanford, CA 94304, USA.
Kai MakitaResearch Center for Child Mental Development, University of Fukui, Fukui, 910-1193, Japan; Division of Developmental Higher Brain Functions, United Graduate School of Child Development, University of Fukui, Fukui, 910-1193, Japan.
Shinichiro TakiguchiDivision of Developmental Higher Brain Functions, United Graduate School of Child Development, University of Fukui, Fukui, 910-1193, Japan; Department of Child and Adolescent Psychological Medicine, University of Fukui Hospital, Fukui, 910-1193, Japan.
Akemi TomodaResearch Center for Child Mental Development, University of Fukui, Fukui, 910-1193, Japan; Division of Developmental Higher Brain Functions, United Graduate School of Child Development, University of Fukui, Fukui, 910-1193, Japan; Department of Child and Adolescent Psychological Medicine, University of Fukui Hospital, Fukui, 910-1193, Japan. Electronic address: atomoda@u-fukui.ac.jp.
Vinod MenonDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94304, USA; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94304, USA; Maternal & Child Health Research Institute, Stanford University, Stanford, CA 94304, USA.
University of Fukui · JPNeurosciences Institute · US

Funding

Mathematical Cognition in Autism: A Cognitive and Systems Neuroscience ApproachR01MH084164 · NIMH · STANFORD UNIVERSITY · PI MENON, VINOD · 2011 to 2021
$6.7M
Methods for Dynamic Causal Interactions in Human Brain Function and DysfunctionR01NS086085 · NINDS · STANFORD UNIVERSITY · PI MENON, VINOD · 2014 to 2025
$3.9M
An integrative framework of cognitive control and reward modulation in children with ADHD: from brain dynamics to clinical symptomsR01MH124816 · NIMH · STANFORD UNIVERSITY · PI CAI, WEIDONG · 2021 to 2025
$3.7M
Computational modeling of dynamic causal brain circuits underlying cognitive dysfunction in Alzheimer's diseaseRF1NS086085 · NINDS · STANFORD UNIVERSITY · PI MENON, VINOD · 2021 to 2021
$2.0M
Novel Bayesian linear dynamical systems-based methods for discovering human brain circuit dynamics in health and diseaseR01EB022907 · NIBIB · STANFORD UNIVERSITY · PI MENON, VINOD · 2016 to 2018
$1.6M
Dynamic Brain Mechanisms of Proactive and Reactive Control in Childhood ADHDK01MH105625 · NIMH · STANFORD UNIVERSITY · PI CAI, WEIDONG · 2015 to 2018
$676k
NIBIB NIH HHS R01 EB022907NIMH NIH HHS K01 MH105625NIMH NIH HHS R01 MH084164NIMH NIH HHS R01 MH124816NINDS NIH HHS R01 NS086085NINDS NIH HHS RF1 NS086085
6 · The paper itself

Abstract

Methylphenidate is a widely used first-line treatment for attention deficit/hyperactivity disorder (ADHD), but the underlying circuit mechanisms are poorly understood. Here we investigate whether a single dose of osmotic release oral system methylphenidate can remediate attention deficits and aberrancies in functional circuit dynamics in cognitive control networks, which have been implicated in ADHD. In a randomized placebo-controlled double-blind crossover design, 27 children with ADHD were scanned twice with resting-state functional MRI and sustained attention was examined using a continuous performance task under methylphenidate and placebo conditions; 49 matched typically-developing (TD) children were scanned once for comparison. Dynamic time-varying cross-network interactions between the salience (SN), frontoparietal (FPN), and default mode (DMN) networks were examined in children with ADHD under both administration conditions and compared with TD children. Methylphenidate improved sustained attention on a continuous performance task in children with ADHD, when compared to the placebo condition. Children with ADHD under placebo showed aberrancies in dynamic time-varying cross-network interactions between the SN, FPN and DMN, which were remediated by methylphenidate. Multivariate classification analysis confirmed that methylphenidate remediates aberrant dynamic brain network interactions. Furthermore, dynamic time-varying network interactions under placebo conditions predicted individual differences in methylphenidate-induced improvements in sustained attention in children with ADHD. These findings suggest that a single dose of methylphenidate can remediate deficits in sustained attention and aberrant brain circuit dynamics in cognitive control circuits in children with ADHD. Findings identify a novel brain circuit mechanism underlying a first-line pharmacological treatment for ADHD, and may inform clinically useful biomarkers for evaluating treatment outcomes.

Indexed as

Attention Deficit Disorder with HyperactivityCentral Nervous System StimulantsMethylphenidateBrainChildDouble-Blind MethodHumansMagnetic Resonance ImagingCentral Nervous System StimulantsMethylphenidateAttention-deficit/hyperactivity disorderCognitive control networkDynamic time-varying cross-network interactionMethylphenidateSalience network

Identifiers

PMID35640787
PMCPMC9286726
OpenAlexW4281714005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.