Evidence map›Paper›PMID 35640677›Full record

ArticleThe American journal of pathology2022

Induction of Transcriptional Inhibitor HES1 and the Related Repression of Tumor-Suppressor TXNIP Are Important Components of Cell-Transformation Program Imposed by Oncogenic Kinase NPM-ALK.

Qian Zhang, Hong Y Wang, Anindita Nayak, Selene Nunez-Cruz, Artur Slupianek, Xiaobin Liu, Johnvesly Basappa, Jing-Song Fan, Seble Chekol, Reza Nejati and 4 more

Open access · greenAbstract read
In one paragraph

Article in The American journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Qian ZhangDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Hong Y WangDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Anindita NayakDepartment of Biological Sciences, National University of Singapore, Singapore.
Selene Nunez-CruzDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Artur SlupianekDepartment of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Xiaobin LiuDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Johnvesly BasappaDepartment of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Jing-Song FanDepartment of Biological Sciences, National University of Singapore, Singapore.
Seble ChekolDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Reza NejatiDepartment of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Agata M BoguszDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Suzanne D TurnerDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Kunchithapadam SwaminathanDepartment of Biological Sciences, National University of Singapore, Singapore.
Mariusz A WasikDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: mariusz.wasik@fccc.edu.
University of Pennsylvania · USFox Chase Cancer Center · USNational University of Singapore · SGUniversity of Cambridge · GB

Funding

Metabolic Biomarkers of Response of Mantle Cell Lymphoma to Bruton Tyrosine Kinase InhibitionR01CA228457 · NCI · UNIVERSITY OF PENNSYLVANIA · PI NATH, KAVINDRA, WASIK, MARIUSZ A. · 2020 to 2024
$2.5M
NCI NIH HHS R01 CA228457
6 · The paper itself

Abstract

This study reports that hairy and enhancer of split homolog-1 (HES1), known to repress gene transcription in progenitor cells of several cell lineages, was strongly expressed in cells and tissues of T-cell lymphoma expressing the oncogenic chimeric tyrosine kinase nucleophosmin (NPM)-anaplastic lymphoma kinase [ALK; ALK

Indexed as

Anaplastic Lymphoma KinaseCarrier ProteinsLymphoma, T-CellTranscription Factor HES-1CarcinogenesisCell Line, TumorHumansOncogenesPhosphorylationAnaplastic Lymphoma KinaseCarrier ProteinsHES1 protein, humanTranscription Factor HES-1TXNIP protein, human

Identifiers

PMID35640677
PMCPMC9379685
OpenAlexW4281955601

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.