Evidence map›Paper›PMID 35640456›Full record

ArticlePlacenta2022

COVID-19 & differential effects in twins: Insights from Placenta Pathology.

Kristen Moriarty, Mingfu Yu, Naveed Hussain, Kinga Zgutka, M Melinda Sanders, Malini Harigopal, Jianhui Wang, Xi Wang, Pei Hui, Chen Liu and 2 more

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Kristen MoriartyDepartment of Obstetrics & Gynecology, University of Connecticut, USA. Electronic address: kmoriarty@uchc.edu.
Mingfu YuDepartment of Pathology, University of Connecticut, USA.
Naveed HussainDepartment of Pediatrics, Connecticut Children's Medical Center, USA.
Kinga ZgutkaDepartment of Pediatrics, Connecticut Children's Medical Center, USA.
M Melinda SandersDepartment of Pathology, University of Connecticut, USA.
Malini HarigopalDepartment of Pathology, Yale University, USA.
Jianhui WangDepartment of Pathology, Yale University, USA.
Xi WangDepartment of Pathology, Yale University, USA.
Pei HuiDepartment of Pathology, Yale University, USA.
Chen LiuDepartment of Pathology, Yale University, USA.
David SinkDepartment of Pediatrics, Connecticut Children's Medical Center, USA.
Andrea ShieldsDepartment of Obstetrics & Gynecology, University of Connecticut, USA.
Yale University · USUniversity of Connecticut · USConnecticut Children's Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCOVID-19 has been associated with several adverse pregnancy outcomes, including perinatal loss. Differential effects of COVID-19 in a twin pregnancy may provide unique insights into virus-placental interactions. We present a case of perinatal loss of a female fetus with survival of the male co-twin in a pregnancy complicated by COVID-19 and premature delivery.

methodsViral detection methods recommended by the NICHD task force were used to identify SARS-CoV-2 and its viral receptors in the placentas and fetal tissue (Antoun et al., 2020) [1]

resultsCompared with the surviving twin, we found a more severe intervillous necrosis and a relatively low detection of ACE2 membranous expression in the syncytiotrophoblasts of the female twin that succumbed. DISCUSSION: The interactions of SARS-CoV-2 and ACE2 at the maternal fetal interface within the placenta may play a significant role in perinatal loss, and the effects of fetal sex and gestational age at time of infection need to be explored further.

Indexed as

COVID-19Pregnancy Complications, InfectiousAngiotensin-Converting Enzyme 2FemaleHumansInfectious Disease Transmission, VerticalMalePlacentaPregnancySARS-CoV-2Angiotensin-Converting Enzyme 2

Identifiers

PMID35640456
PMCPMC9121647
OpenAlexW4280584000

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.