Evidence map›Paper›PMID 35640320›Full record

ArticleCortex; a journal devoted to the study of the nervous system and behavior2022

Reduced asymmetry of the hand knob area and decreased sensorimotor u-fiber connectivity in middle-aged adults with autism.

Janice Hau, Ashley Baker, Chantal Chaaban, Jiwandeep S Kohli, R Joanne Jao Keehn, Annika C Linke, Lisa E Mash, Molly Wilkinson, Mikaela K Kinnear, Ralph-Axel Müller and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Cognitive and Cerebral Aging Research in Autism: A Systematic Review on an Emerging Topic.Autism research : official journal of the International Society for Autism Research · 2025
    Pooled it
  2. Review
  3. Review
  4. Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Janice HauBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, USA.
Ashley BakerBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, USA.
Chantal ChaabanBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, USA.
Jiwandeep S KohliBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, USA.
R Joanne Jao KeehnBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, USA.
Annika C LinkeBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, USA.
Lisa E MashBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, USA.
Molly WilkinsonBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, USA.
Mikaela K KinnearBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, USA.
Ralph-Axel MüllerBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, USA.
Ruth A CarperBrain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, CA, USA. Electronic address: rcarper@sdsu.edu.
San Diego State University · US

Funding

The Autistic Brain Over 45: The Anatomic, Functional, and Cognitive PhenotypeR01MH103494 · NIMH · SAN DIEGO STATE UNIVERSITY · PI CARPER, RUTH, MUELLER, RALPH-AXEL · 2015 to 2025
$7.0M
NIMH NIH HHS R01 MH103494
6 · The paper itself

Abstract

Individuals with autism spectrum disorder (ASD) frequently present with impairments in motor skills (e.g., limb coordination, handwriting and balance), which are observed across the lifespan but remain largely untreated. Many adults with ASD may thus experience adverse motor outcomes in aging, when physical decline naturally occurs. The 'hand knob' of the sensorimotor cortex is an area that is critical for motor control of the fingers and hands. However, this region has received little attention in ASD research, especially in adults after midlife. The hand knob area of the precentral (PrC

Indexed as

Autism Spectrum DisorderAutistic DisorderWhite MatterAdultBayes TheoremHumansMagnetic Resonance ImagingMiddle AgedAutismHemispheric asymmetryMiddle-ageSensorimotorU-fibers

Identifiers

PMID35640320
PMCPMC9988270
OpenAlexW4280628179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.