SynthesisThe British journal of surgery2022
Endoscopic vacuum therapy and early surgical closure after pelvic anastomotic leak: meta-analysis of bowel continuity rates.
Synthesis in The British journal of surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Infection-targeted innovations in anastomotic leak management: endoscopic advances, antimicrobial biomaterials, and precision strategies.Annals of medicine · 2026Review
- Prevention, Recognition, and Management of Anastomotic Leakage and Pelvic Sepsis After Rectal Cancer Surgery: A Structured Narrative Review.Journal of clinical medicine · 2026Review
- Ultra-early postoperative endoscopy reduces anastomotic leak after minimally invasive esophagectomy: a propensity score-matched study.Surgical endoscopy · 2026Article
- Interventional Endoscopy for the Management of Post-Surgical Leaks and Fistulas: A Scoping Review.Journal of clinical medicine · 2026Review
- Diagnostic accuracy of C-reactive protein in detecting anastomotic leakage after minimally invasive rectal cancer surgery.Surgical endoscopy · 2026Article
- Hospital costs of different treatment strategies for anastomotic leakage after total mesorectal excision: a multicentre cost analysis.Techniques in coloproctology · 2025Article
- Endoscopic purse-string suture technique for postoperative drain-related leakage management in gastrointestinal surgery.BMC surgery · 2025Article
- Endoscopic Management of Anastomotic Insufficiencies in the Lower GI Tract.Visceral medicine · 2025Review
- Endoscopic vacuum therapy: pitfalls, tips and tricks, insights, and perspectives.Translational gastroenterology and hepatology · 2024Review
- Successful treatment of anastomotic leakage with an intestinal obstruction catheter and stent by colonoscopy: a case report and brief literature review.Frontiers in oncology · 2024Article
- Stoma-free survival after anastomotic leak following rectal cancer resection: worldwide cohort of 2470 patients.The British journal of surgery · 2023Article
- Endoscopic Vacuum Therapy: When and How to Use It?GE Portuguese journal of gastroenterologyReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndoscopic vacuum therapy (EVT) with or without early surgical closure (ESC) is considered an effective option in the management of pelvic anastomotic leakage. This meta-analysis evaluated the effectiveness of EVT in terms of stoma reversal rate and the added value of ESC.
methodsA systematic search of PubMed, MEDLINE, and the Cochrane Library was conducted in November 2021 to identify articles on EVT in adult patients with pelvic anastomotic leakage. The primary outcome was restored continuity rate. Following PRISMA guidelines, a meta-analysis was undertaken using a random-effects model.
resultsTwenty-nine studies were included, accounting for 827 patients with leakage who underwent EVT. There was large heterogeneity between studies in design and reported outcomes, and a high risk of bias. The overall weighted mean restored continuity rate was 66.8 (95 per cent c.i. 58.8 to 73.9) per cent. In patients undergoing EVT with ESC, the calculated restored continuity rate was 82 per cent (95 per cent c.i. 50.1 to 95.4) as compared to 64.7 per cent (95 per cent c.i. 55.7 to 72.7) after EVT without ESC. The mean number of sponge exchanges was 4 (95 per cent c.i. 2.7 to 4.6) and 9.8 (95 per cent c.i. 7.3 to 12.3), respectively. Sensitivity analysis showed a restored continuity rate of 81 per cent (95 per cent c.i. 55.8 to 99.5) for benign disease, 69.0 per cent (95 per cent c.i. 57.3 to 78.7) for colorectal cancer, and 65 per cent (95 per cent c.i. 48.8 to 79.1) if neoadjuvant radiotherapy was given.
conclusionEVT is associated with satisfactory stoma reversal rates that may be improved if it is combined with ESC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.