Evidence map›Paper›PMID 35640057›Full record

ArticleThe neuroradiology journal2022

Pre-styloid parapharyngeal space masses-Tumor margins as a predictor of benign versus malignant histology on pre-operative CT or MRI.

Nicholas Vargas, Reza Assadsangabi, Andrew Birkeland, Arnaud Bewley, Kenneth Broadhead, Megan Morisada, Vladimir Ivanovic

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The neuroradiology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. The transcervical-transparotid corridor for management of parapharyngeal space neoplasms: strengths and limits in a bi-institutional retrospective series.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Review
  4. Primary Pathology of the Parapharyngeal Space.Clinical neuroradiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nicholas VargasDepartment of Radiology, Section of Neuroradiology, 70083University of California Davis Medical Center, Sacramento, CA, USA.ORCID 0000-0002-8294-7622
Reza AssadsangabiDepartment of Radiology, Section of Neuroradiology, 70083University of California Davis Medical Center, Sacramento, CA, USA.
Andrew BirkelandDepartment of Otolaryngology, 70083University of California Davis Medical Center, Sacramento, CA, USA.
Arnaud BewleyDepartment of Otolaryngology, 70083University of California Davis Medical Center, Sacramento, CA, USA.
Kenneth BroadheadDepartment of Statistics, 8789University of California Davis, Davis, CA, USA.
Megan MorisadaDepartment of Otolaryngology, 70083University of California Davis Medical Center, Sacramento, CA, USA.
Vladimir IvanovicDepartment of Radiology, Section of Neuroradiology, 70083University of California Davis Medical Center, Sacramento, CA, USA.
University of California Davis Medical Center · USUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEvaluate the frequency of benign versus malignant masses within the prestyloid parapharyngeal space (PPS) and determine if tumor margins on preoperative cross-sectional imaging can predict malignancy status. MATERIALS AND

methodsThe electronic health record at UC Davis Medical Center was searched for PPS masses surgically resected between 2015 and 2021. Cases located centrally within the prestyloid PPS with confirmed histologic diagnosis were included and separated into either benign or malignant groups. Margins of the tumors were categorized as "well defined" or "infiltrative" on preoperative cross-sectional imaging. Statistical analysis was performed to evaluate relationships between malignancy status and tumor margins.

resultsA total of 31 cases met the inclusion criteria. Fourteen separate histologic diagnoses were observed. Benign cases comprised 77% (24/31) and the remaining 23% (7/31) were malignant. Pleomorphic adenoma was the most common overall diagnosis at 48% (15/31). Adenoid cystic carcinoma 6% (2/31) was the most common malignant diagnosis. Well-defined tumor margins were seen in 81% (25/31) of cases. A benign diagnosis was found in 96% (24/25) of the cases with well-defined margins. Infiltrative tumor margins were displayed in 19% (6/31) of cases, all were malignant. The sensitivity and specificity of infiltrative tumor margins for malignancy were 85.7% and 100%, respectively. The negative predictive value of infiltrative margins for malignancy was 96%.

conclusionInfiltrative tumor margins on preoperative imaging demonstrate high specificity and negative predictive value for malignant histology in prestyloid PPS masses. Margins should therefore be considered when determining clinical management for newly diagnosed PPS tumors.

Indexed as

Adenoma, PleomorphicParapharyngeal SpaceHumansMagnetic Resonance ImagingRetrospective StudiesTomography, X-Ray Computedinfiltrative marginsParapharyngeal spacePPS tumorsprestyloid PPS

Identifiers

PMID35640057
PMCPMC9626845
OpenAlexW4281624432

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.