ArticlePlant physiology2022
Phosphate transporter PHT1;1 is a key determinant of phosphorus acquisition in Arabidopsis natural accessions.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 33 citations in OpenAlex.
- Transcription factors in phosphorus utilization: enhancing crop productivity and stress resilience.Planta · 2026Review
- Phosphate Transporters Mediate the Uptake of Monothioarsenate.Plant, cell & environment · 2026Article
- Integration of proteomic, metabolomic, and ubiquitinomic analyses reveals potential mechanisms underlying low-phosphorus stress adaptation in soybean roots.BMC plant biology · 2026Article
- Deciphering the role of NtabCrRLK47 in rhizosphere microbiome remodeling and tobacco growth promotion.Frontiers in plant science · 2026Article
- Comparative analysis of seven types of phosphate transporters in forty species from the phylogenetic and transcriptomic perspective.PloS one · 2026Article
- Organ-specific transcriptional and metabolic adaptations of potato plants to limited phosphate availability prior and after tuberization.The Plant journal : for cell and molecular biology · 2025Article
- Genome-wide identification of MYB gene family and exploration of selenium metabolism-related candidates in paper mulberry (Broussonetia papyrifera).Plant cell reports · 2025Article
- The AP2/ERF Transcription Factor ERF56 Negatively Regulating Nitrate-Dependent Plant Growth inInternational journal of molecular sciences · 2025Article
- From genes to traits: maximizing phosphorus utilization efficiency in crop plants.Frontiers in plant science · 2025Review
- Article
- The Myb73-GDPD2-GA2ox1 transcriptional regulatory module confers phosphate deficiency tolerance in soybean.The Plant cell · 2024Article
- Recent advances in research on phosphate starvation signaling in plants.Journal of plant research · 2024Review
- Update of phosphate transport regulations.Journal of plant research · 2024Article
- Traits linked to natural variation of sulfur content in Arabidopsis thaliana.Journal of experimental botany · 2024Article
- Phosphate TransporterPlants (Basel, Switzerland) · 2023Article
- Multi-Omics Analysis Reveals Mechanisms of Strong Phosphorus Adaptation in Tea Plant Roots.International journal of molecular sciences · 2023Article
- Chloroplastic Sec14-like proteins modulate growth and phosphate deficiency responses in Arabidopsis and rice.Plant physiology · 2023Article
- Five Post-Translational Modification Residues of CmPT2 Play Key Roles in Yeast and Rice.International journal of molecular sciences · 2023Article
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7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphorus (P) is a mineral nutrient essential for plant growth and development, but most P in the soil is unavailable for plants. To understand the genetic basis of P acquisition regulation, we performed genome-wide association studies (GWASs) on a diversity panel of Arabidopsis (Arabidopsis thaliana). Two primary determinants of P acquisition were considered, namely, phosphate (Pi)-uptake activity and PHOSPHATE TRANSPORTER 1 (PHT1) protein abundance. Association mapping revealed a shared significant peak on chromosome 5 (Chr5) where the PHT1;1/2/3 genes reside, suggesting a connection between the regulation of Pi-uptake activity and PHT1 protein abundance. Genes encoding transcription factors, kinases, and a metalloprotease associated with both traits were also identified. Conditional GWAS followed by statistical analysis of genotype-dependent PHT1;1 expression and transcriptional activity assays revealed an epistatic interaction between PHT1;1 and MYB DOMAIN PROTEIN 52 (MYB52) on Chr1. Further, analyses of F1 hybrids generated by crossing two subgroups of natural accessions carrying specific PHT1;1- and MYB52-associated single nucleotide polymorphisms (SNPs) revealed strong effects of these variants on PHT1;1 expression and Pi uptake activity. Notably, the soil P contents in Arabidopsis habitats coincided with PHT1;1 haplotype, emphasizing how fine-tuned P acquisition activity through natural variants allows environmental adaptation. This study sheds light on the complex regulation of P acquisition and offers a framework to systematically assess the effectiveness of GWAS approaches in the study of quantitative traits.
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