ArticlePLoS biology2022
Learning-related congruent and incongruent changes of excitation and inhibition in distinct cortical areas.
Article in PLoS biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Reassessing Choice Probability: What 59 Macaque Studies Tell Us About Decision-Related Activity in Visual Cortex.bioRxiv : the preprint server for biology · 2026Article
- Neural correlates of perceptual decision-making in the primary somatosensory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Distinct roles of cortical layer 5 subtypes in associative learning.Nature communications · 2026Article
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- Amygdala and Cortex Relationships during Learning of a Sensory Discrimination Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The secondary somatosensory cortex gates mechanical and heat sensitivity.Nature communications · 2024Article
- Oscillatory beta/alpha band modulations: A potential biomarker of functional language and motor recovery in chronic stroke?Frontiers in human neuroscience · 2022Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excitatory and inhibitory neurons in diverse cortical regions are likely to contribute differentially to the transformation of sensory information into goal-directed motor plans. Here, we investigate the relative changes across mouse sensorimotor cortex in the activity of putative excitatory and inhibitory neurons-categorized as regular spiking (RS) or fast spiking (FS) according to their action potential (AP) waveform-comparing before and after learning of a whisker detection task with delayed licking as perceptual report. Surprisingly, we found that the whisker-evoked activity of RS versus FS neurons changed in opposite directions after learning in primary and secondary whisker motor cortices, while it changed similarly in primary and secondary orofacial motor cortices. Our results suggest that changes in the balance of excitation and inhibition in local circuits concurrent with changes in the long-range synaptic inputs in distinct cortical regions might contribute to performance of delayed sensory-to-motor transformation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.