ArticleThe Plant cell2022
Ustilaginoidea virens secretes a family of phosphatases that stabilize the negative immune regulator OsMPK6 and suppress plant immunity.
Article in The Plant cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 53 citations in OpenAlex.
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- Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Decoding MAPK cascades in plant immunity: Activation, regulation, integration, and pathogen manipulation.Journal of integrative plant biology · 2026Review
- A conserved phospho-switch controls receptor kinase SDS2 activation and homeostasis in rice immunity.Science advances · 2026Article
- A comprehensive exploration of molecular aspects of rice-Ustilaginoidea virens interactions.Plant molecular biology · 2026Review
- An Ustilaginoidea virens Nuclear Effector SCRE7 Inhibits Rice Immunity via Suppressing OsLBD11/12-Promoted Transcription of OsCPS2.Plant biotechnology journal · 2026Article
- Type one protein phosphatases (TOPPs) catalyze EIN2 dephosphorylation to regulate ethylene signaling inScience advances · 2026Article
- OsRNS4-mediated cross-kingdom RNA interference is inhibited byScience advances · 2026Article
- The SWI/SNF complex subunit CgSwi1 is indispensable for host-derived ROS scavenging and infectious growth inVirulence · 2025Article
- Fumarylacetoacetate hydrolase targeted by a Fusarium graminearum effector positively regulates wheat FHB resistance.Nature communications · 2025Article
- E3-Ubiquitin Ligase SgATL31 Promotes Anthracnose Resistance in Stylosanthes by Modulating ROS Burst and Antioxidant Defence: A Proteomic and Functional Study.Molecular plant pathology · 2025Article
- AScience advances · 2025Article
- Genome-wide characterization of effector proteins in Fusarium zanthoxyli and their effects on plant's innate immunity responses.BMC plant biology · 2025Article
- Targeting effector proteins of plant pathogens as a strategy for durable plant disease resistance.Frontiers in microbiology · 2025Article
- A secreted fungal laccase targets the receptor kinase OsSRF3 to inhibit OsBAK1-OsSRF3-mediated immunity in rice.Nature communications · 2024Article
- CRISPR-targeted mutagenesis of mitogen-activated protein kinase phosphatase 1 improves both immunity and yield in wheat.Plant biotechnology journal · 2024Article
- Rice false smut virulence protein subverts host chitin perception and signaling at lemma and palea for floral infection.The Plant cell · 2024Article
- The OsCPK17-OsPUB12-OsRLCK176 module regulates immune homeostasis in rice.The Plant cell · 2024Article
- UvHOS3-mediated histone deacetylation is essential for virulence and negatively regulates ustilaginoidin biosynthesis in Ustilaginoidea virens.Molecular plant pathology · 2024Article
- Ustilaginoidea virens-secreted effector Uv1809 suppresses rice immunity by enhancing OsSRT2-mediated histone deacetylation.Plant biotechnology journal · 2024Article
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14 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Rice false smut caused by Ustilaginoidea virens is emerging as a devastating disease of rice (Oryza sativa) worldwide; however, the molecular mechanisms underlying U. virens virulence and pathogenicity remain largely unknown. Here we demonstrate that the small cysteine-rich secreted protein SCRE6 in U. virens is translocated into host cells during infection as a virulence factor. Knockout of SCRE6 leads to attenuated U. virens virulence to rice. SCRE6 and its homologs in U. virens function as a novel family of mitogen-activated protein kinase phosphatases harboring no canonical phosphatase motif. SCRE6 interacts with and dephosphorylates the negative immune regulator OsMPK6 in rice, thus enhancing its stability and suppressing plant immunity. Ectopic expression of SCRE6 in transgenic rice promotes pathogen infection by suppressing the host immune responses. Our results reveal a previously unidentified fungal infection strategy in which the pathogen deploys a family of tyrosine phosphatases to stabilize a negative immune regulator in the host plant to facilitate its infection.
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