Evidence map›Paper›PMID 35639293›Full record

ArticleAnnals of surgical oncology2022

Socioeconomic Barriers to CRS HIPEC for Appendiceal Cancer within a Regional Academic Hospital System.

Caroline Rieser, Heather Phelos, Amer Zureikat, James Pingpank, Melanie Ongchin, Andrew Lee, Joshua Brown, M Haroon Choudry, Richard S Hoehn

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Caroline RieserDivision of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Heather PhelosDivision of Trauma and Acute Care Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Amer ZureikatDivision of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
James PingpankDivision of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Melanie OngchinDivision of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Andrew LeeDivision of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Joshua BrownDivision of Trauma and Acute Care Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
M Haroon ChoudryDivision of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Richard S HoehnDivision of Surgical Oncology, University Hospitals, Cleveland, OH, USA. Richard.Hoehn@UHhospitals.org.
University of Pittsburgh Medical Center · USUniversity Hospitals of Cleveland · US

Funding

Postdoctoral Research Training in Biotherapy of CancerT32CA113263 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Udai S Kammula · 2006 to 2026
$3.6M
NCI NIH HHS T32 CA113263
6 · The paper itself

Abstract

backgroundAppendiceal cancer with peritoneal metastases (ACPM) is a complex disease requiring multidisciplinary care. Cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion (CRS HIPEC) can significantly improve survival but requires evaluation by a surgical oncologist and significant treatment endurance. The impacts of socioeconomic status (SES) and other social determinants of health on rates of surgical evaluation and treatment have not been examined.

methodsWe conducted a retrospective cohort study examining all patients with ACPM from 2010 to 2018 in a regional healthcare system. Patient characteristics, oncologic details, treatment strategies, and survival were examined. The primary outcomes of interest were referral to Surgical Oncology, receipt of CRS HIPEC, and survival.

resultsOf 194 patients identified, 94% had synchronous ACPM. The majority of patients (95%) were referred to surgical oncology. Advanced age was the only predictor of nonreferral (p < 0.001). A total of 147 patients (76%) ultimately underwent CRS HIPEC. After adjusting for medical and tumor characteristics, CRS HIPEC was less likely for patients who were unmarried [odds ratio (OR) 0.253, p = 0.004] or of low SES (OR 0.372, p = 0.03). On subanalysis of patients undergoing CRS HIPEC, median overall survival was worse for patients of low SES [51 months versus not reached (NR), p = 0.05], and this disparity persisted on multivariate analysis [hazard ratio (HR) = 2.278, p = 0.001].

conclusionsThis analysis is the first to evaluate barriers to CRS HIPEC for ACPM. While most patients were evaluated by a multidisciplinary team, nonmedical factors may play a role in the treatment received and ultimate outcomes. Addressing these disparities is crucial for ensuring equitable outcomes and improving patient care.

Indexed as

Appendiceal NeoplasmsHyperthermia, InducedAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyCytoreduction Surgical ProceduresHospitalsHumansHyperthermic Intraperitoneal ChemotherapyIncomeRetrospective StudiesSurvival Rate

Identifiers

PMID35639293
PMCPMC9547669
OpenAlexW4281717709

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.