Evidence map›Paper›PMID 35639246›Full record

ArticleArchives of pharmacal research2022

Physiologically based pharmacokinetic (PBPK) modeling of piroxicam with regard to CYP2C9 genetic polymorphism.

Chang-Keun Cho, Pureum Kang, Hye-Jung Park, Eunvin Ko, Chou Yen Mu, Yun Jeong Lee, Chang-Ik Choi, Hyung Sik Kim, Choon-Gon Jang, Jung-Woo Bae and 1 more

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Article in Archives of pharmacal research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  9. Article
  10. Metabolites · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chang-Keun Cho *School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Pureum Kang *School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Hye-Jung Park *School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Eunvin KoSchool of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Chou Yen MuSchool of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Yun Jeong LeeCollege of Pharmacy, Dankook University, Cheonan, 31116, Republic of Korea.
Chang-Ik ChoiCollege of Pharmacy, Dongguk University-Seoul, Goyang, 10326, Republic of Korea.
Hyung Sik KimSchool of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Choon-Gon JangSchool of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Jung-Woo BaeCollege of Pharmacy, Keimyung University, Daegu, 42601, Republic of Korea. jwbae11@kmu.ac.kr.
Seok-Yong LeeSchool of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea. sylee@skku.edu.ORCID http://orcid.org/0000-0003-4162-1981

Funding

National Research Foundation NRF-2019R1A2C1004582
6 · The paper itself

Abstract

Piroxicam is a non-steroidal anti-inflammatory drug used to alleviate symptoms of osteoarthritis and rheumatoid arthritis. CYP2C9 genetic polymorphism significantly influences the pharmacokinetics of piroxicam. The objective of this study was to develop and validate the piroxicam physiologically based pharmacokinetic (PBPK) model related to CYP2C9 genetic polymorphism. PK-Sim

Indexed as

Models, BiologicalPiroxicamAnti-Inflammatory Agents, Non-SteroidalCytochrome P-450 CYP2C9Polymorphism, GeneticAnti-Inflammatory Agents, Non-SteroidalCytochrome P-450 CYP2C9PiroxicamCYP2C9Genetic polymorphismPharmacokineticsPhysiologically based pharmacokinetic (PBPK) modelPiroxicam

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.