Evidence map›Paper›PMID 35639234›Full record

ArticleInflammopharmacology2022

Syringol isolated from Eleusine coracana (L.) Gaertn bran suppresses inflammatory response through the down-regulation of cPLA

M D Milan Gowda, K Jayachandra, Vikram Joshi, Vaddarahally N Manjuprasanna, Gotravalli V Rudresha, Devadasan Velmurugan, Raman Pachaiappan, Noor Mohamed Jameel, Bannikuppe S Vishwanath

Abstract read
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In one paragraph

Article in Inflammopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Cell-Free DNA-Based Theranostics for Inflammatory Disorders.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Article
  3. Protective Effects of Hemp (Molecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

M D Milan GowdaDepartment of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India.
K JayachandraDepartment of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India.
Vikram JoshiDivision of Gastroenterology and Hepatology, Enteric NeuroScience Program, Mayo Clinic, Rochester, MN, USA.
Vaddarahally N ManjuprasannaDepartment of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India.
Gotravalli V RudreshaDepartment of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India.
Devadasan VelmuruganCentre of Advanced Study in Crystallography and Biophysics, University of Madras, Chennai, Tamil Nadu, India.
Raman PachaiappanDepartment of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.
Noor Mohamed JameelDepartment of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India. jameel.nm@gmail.com.
Bannikuppe S VishwanathDepartment of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India. vishmy@biochemistry.uni-mysore.ac.in.ORCID http://orcid.org/0000-0003-3284-4163
University of Mysore · INMayo Clinic in Arizona · USSRM Institute of Science and Technology · INUniversity of Madras · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eleusine coracana (L.) Gaertn (E. coracana) is one of the highest consuming food crops in Asia and Africa. E. coracana is a plant with several medicinal values including anti-ulcerative, anti-diabetic, anti-viral and anti-cancer properties. However, the anti-inflammatory property of E. coracana remains to be elucidated. Therefore, the objective of present study was to investigate the potential in isolated molecule from E. coracana via a combination of in vitro, in vivo and in silico methods. In this study, we have isolated, purified and characterized an anti-inflammatory molecule from E. coracana bran extract known as syringol. Purification of syringol was accomplished by combination of GC-MS and RP-HPLC techniques. Syringol significantly inhibited the enzymes activity of sPLA

Indexed as

EleusinePhospholipases A2, SecretoryAnimalsAnti-Inflammatory AgentsCalciumCarrageenanCyclooxygenase 2Down-RegulationEdemaMiceMolecular Docking SimulationNF-KappaB Inhibitor alphaPlant ExtractsPyrogallolAnti-Inflammatory AgentsCalciumCarrageenanCyclooxygenase 2NF-KappaB Inhibitor alphaPhospholipases A2, SecretoryPlant ExtractsPyrogallolpyrogallol 1,3-dimethyl etherArachidonic acidCyclooxygenase and inflammationEleusine coracanaLipoxygenaseSecretory phospholipase A2

Identifiers

PMID35639234
OpenAlexW4281790455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.