Evidence map›Paper›PMID 35639224›Full record

ArticleMolecular diversity2023

External oxidant-free and transition metal-free synthesis of 5-amino-1,2,4-thiadiazoles as promising antibacterials against ESKAPE pathogen strains.

Anton Shetnev, Marina Tarasenko, Valentina Kotlyarova, Sergey Baykov, Kirill Geyl, Svetlana Kasatkina, Nikolina Sibinčić, Vladimir Sharoyko, Elizaveta V Rogacheva, Liudmila A Kraeva

Abstract read
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In one paragraph

Article in Molecular diversity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anton ShetnevPharmaceutical Technology Transfer Centre, Yaroslavl State Pedagogical University Named After K.D. Ushinsky, Yaroslavl, Russian Federation, 150000. a.shetnev@list.ru.ORCID http://orcid.org/0000-0002-4389-461X
Marina TarasenkoPharmaceutical Technology Transfer Centre, Yaroslavl State Pedagogical University Named After K.D. Ushinsky, Yaroslavl, Russian Federation, 150000.ORCID http://orcid.org/0000-0001-5720-2664
Valentina KotlyarovaPharmaceutical Technology Transfer Centre, Yaroslavl State Pedagogical University Named After K.D. Ushinsky, Yaroslavl, Russian Federation, 150000.ORCID http://orcid.org/0000-0001-5404-2829
Sergey BaykovInstitute of Chemistry, Saint Petersburg State University, Universitetskaya Nab., 7/9, Saint Petersburg, Russian Federation, 199034.ORCID http://orcid.org/0000-0002-8912-5816
Kirill GeylInstitute of Chemistry, Saint Petersburg State University, Universitetskaya Nab., 7/9, Saint Petersburg, Russian Federation, 199034.ORCID http://orcid.org/0000-0002-2016-1894
Svetlana KasatkinaInstitute of Chemistry, Saint Petersburg State University, Universitetskaya Nab., 7/9, Saint Petersburg, Russian Federation, 199034.ORCID http://orcid.org/0000-0002-7943-7525
Nikolina SibinčićInstitute of Chemistry, Saint Petersburg State University, Universitetskaya Nab., 7/9, Saint Petersburg, Russian Federation, 199034.ORCID http://orcid.org/0000-0001-7154-4214
Vladimir SharoykoInstitute of Chemistry, Saint Petersburg State University, Universitetskaya Nab., 7/9, Saint Petersburg, Russian Federation, 199034.ORCID http://orcid.org/0000-0002-3717-0471
Elizaveta V RogachevaSaint Petersburg Pasteur Institute, 14 Mira Street, Saint Petersburg, Russian Federation, 197101.ORCID http://orcid.org/0000-0002-3843-0685
Liudmila A KraevaSaint Petersburg Pasteur Institute, 14 Mira Street, Saint Petersburg, Russian Federation, 197101.ORCID http://orcid.org/0000-0002-9115-3250

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new route to 5-amino-1,2,4-thiadiazole derivatives via reaction of N-chloroamidines with isothiocyanates has been proposed. The advantages of this method are high product yields (up to 93%), the column chromatography-free workup procedure, scalability and the absence of additive oxidizing agents or transition metal catalysts. The 28 examples of 5-amino-1,2,4-thiadiazole derivatives obtaining via the proposing protocol were evaluated in vitro against ESKAPE pathogens strains (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter cloacae). It was found that compounds 5ba, 5bd, 6a, 6d and 6c have potent antibacterial activity (MIC values 0.09-1.5 μg mL

Indexed as

Anti-Infective AgentsEnterococcus faeciumAnti-Bacterial AgentsKlebsiella pneumoniaeStaphylococcus aureusAnti-Bacterial AgentsAnti-Infective AgentsAmidinesAntimicrobialESKAPEHeterocyclesIsothiocyanates

Identifiers

PMID35639224

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.