Evidence map›Paper›PMID 35639001›Full record

ArticleMicrobiology spectrum2022

Genomic Traits Associated with Virulence and Antimicrobial Resistance of Invasive Group B Streptococcus Isolates with Reduced Penicillin Susceptibility from Elderly Adults.

Shota Koide, Yukiko Nagano, Shino Takizawa, Kanae Sakaguchi, Eiji Soga, Wataru Hayashi, Mizuki Tanabe, Tomohiro Denda, Kouji Kimura, Yoshichika Arakawa and 1 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Descriptive review: global spectrum of invasive group B streptococcal disease in nonpregnant adults: epidemiology, risk factors and clinical presentations.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  2. Clinical and molecular characteristics of Streptococcus agalactiae bacteremia in nonpregnant adults: a single-center analysis over 16 years in Hiroshima, Japan.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  3. First case of penicillin-resistantEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  4. Penicillin-Binding Proteins inAntibiotics (Basel, Switzerland) · 2026
    Review
  5. Article
  6. Genomic characterization of group BMicrobial genomics · 2025
    Article
  7. Article
  8. Article
  9. Emergence of High-Level Gentamicin Resistance inAntibiotics (Basel, Switzerland) · 2024
    Article
  10. Article
  11. Article
  12. Serotype distribution and antibiogram ofMicrobiology spectrum · 2023
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Shota KoideDepartment of Medical Sciences, Shinshu University Graduate School of Medicine, Science and Technology, Matsumoto, Japan.
Yukiko NaganoDepartment of Health and Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
Shino TakizawaDepartment of Health and Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
Kanae SakaguchiDepartment of Health and Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
Eiji SogaDepartment of Health and Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
Wataru HayashiDepartment of Medical Sciences, Shinshu University Graduate School of Medicine, Science and Technology, Matsumoto, Japan.ORCID 0000-0003-3430-8524
Mizuki TanabeDepartment of Health and Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
Tomohiro DendaDepartment of Health and Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
Kouji KimuraNagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-3783-6333
Yoshichika ArakawaNagoya University Graduate School of Medicine, Nagoya, Japan.
Noriyuki NaganoDepartment of Medical Sciences, Shinshu University Graduate School of Medicine, Science and Technology, Matsumoto, Japan.ORCID 0000-0002-3657-8029
Shinshu University · JPNagoya University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate genomic traits underlying the antimicrobial resistance and virulence of multidrug-resistant (MDR) group B streptococci with reduced penicillin susceptibility (PRGBS) recovered from elderly patients with bloodstream infections, which remain poorly characterized. The pangenome was found to be open, with the predicted pan- and core genome sizes being 3,531 and 1,694 genes, respectively. Accessory and unique genes were enriched for the Clusters of Orthologous Groups (COG) categories L, Replication, recombination, and repair, and K, Transcription. All MDR PRGBS isolates retained a core virulence gene repertoire (

Indexed as

BacteremiaStreptococcal InfectionsAdultAgedAnti-Bacterial AgentsDrug Resistance, BacterialGenomicsHumansInfant, NewbornMicrobial Sensitivity TestsPenicillinsPhylogenyStreptococcus agalactiaeVirulenceAnti-Bacterial AgentsPenicillinsbacteremiaelderly adultsgroup B streptococcipenicillin nonsusceptible

Identifiers

PMID35639001
PMCPMC9241772
OpenAlexW4281653423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.