Observational studyRadiology2022
MRI-based Texture Analysis of Infrapatellar Fat Pad to Predict Knee Osteoarthritis Incidence.
Open access · greenAbstract readObservational Study
In one paragraph
Observational study in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
12.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 79 citations in OpenAlex.
- Application characteristics and clinical effectiveness of clinical finding staging in guiding non-surgical treatment of knee osteoarthritis involving 92 medical institutions.Journal of orthopaedic surgery and research · 2024Trial
- Ultrasound Characteristics of the Infrapatellar Fat Pad Under Physiological and Pathological Conditions.Sports medicine - open · 2026Review
- Advances in heterogeneity and classification of osteoarthritis.Bone research · 2026Review
- Wnt/β-catenin signaling regulates fibrotic atrophy of intra-articular adipose tissue in post-traumatic osteoarthritis.bioRxiv : the preprint server for biology · 2026Article
- The Infrapatellar Fat Pad in Osteoarthritis: From Pathophysiology to a Novel Therapeutic Target.International journal of molecular sciences · 2026Review
- The infrapatellar fat pad mediates environmental exposure for clinical outcomes in knee osteoarthritis.Osteoarthritis and cartilage open · 2026Article
- Evaluating the predictive efficacy of multi-parameter MRI based radiomic models on clinical symptom progression in perforator artery cerebral infarction.BMC medical imaging · 2026Article
- Multi-Omics Reveal the Dysregulated Gut-Joint Axis in Knee Synovitis: Data from Two Osteoarthritis Studies in China.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Machine learning predicts clinical response to platelet-rich plasma therapy in knee osteoarthritis.Frontiers in medicine · 2026Article
- MRI-based radiomics to determine the role of thigh muscle quality in the development of knee osteoarthritis: A discovery and validation study.Journal of advanced research · 2026Article
- Correlation Between T1 Rho Value of Magnetic Resonance and Clinical Characteristics of Patients with Knee Osteoarthritis and Analysis of Related Factors of T1 Rho Value.International journal of general medicine · 2026Article
- Clinical value of biomechanics and magnetic resonance imaging in the evaluation of knee osteoarthritis.Frontiers in surgery · 2026Article
- Associated factors influencing pain and slower gait speed in older adults with knee osteoarthritis: a cross-sectional study.Frontiers in medicine · 2026Article
- Inflammatory gradients in the infrapatellar fat pad of knee osteoarthritis: implications for joint damage.Arthritis research & therapy · 2025Article
- Exploratory analysis of infrapatellar fat pad MRI-based radiomics for detection of knee structure abnormalities in collegiate basketball players and swimmers.Osteoarthritis imaging · 2025Article
- The role of the infrapatellar fat pad in osteoporotic knee osteoarthritis: bone-fat crosstalk: cross-sectional studies.Journal of orthopaedic surgery and research · 2025Article
- Recent evolution in imaging techniques for assessment of synovitis in osteoarthritis.Skeletal radiology · 2025Review
- Three-Dimensional gait biomechanics in patients with mild knee osteoarthritis.Scientific reports · 2025Article
- A novel infrapatellar fat pad preservation technique in anterior cruciate ligament reconstruction reduces postoperative pain and cartilage damage: a retrospective study.Journal of orthopaedic surgery and research · 2025Article
- Radiomic features of infrapatellar fat pad are associated with knee symptoms and radiographic post-traumatic osteoarthritis at 10+ years after anterior cruciate ligament reconstruction.Osteoarthritis imaging · 2025Article
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 4 countries.
Jia Li *From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).ORCID 0000-0003-3572-3690
Shuai Fu *From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).ORCID 0000-0001-9853-9298
Ze GongFrom the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).ORCID 0000-0003-2091-9973
Zhaohua ZhuFrom the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).ORCID 0000-0003-3913-2564
Dong ZengFrom the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).ORCID 0000-0001-6015-5010
Peihua CaoFrom the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).ORCID 0000-0003-4269-3899
Ting LinFrom the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).ORCID 0000-0003-3825-6178
Tianyu ChenFrom the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).ORCID 0000-0001-7056-2947
Xiaoshuai WangFrom the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).ORCID 0000-0002-3895-1384
Richard LarteyFrom the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).ORCID 0000-0002-8336-7363
C Kent KwohFrom the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).ORCID 0000-0001-5937-550X
Ali GuermaziFrom the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).ORCID 0000-0002-9374-8266
Frank W RoemerFrom the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).ORCID 0000-0001-9238-7350
David J HunterFrom the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).ORCID 0000-0003-3197-752X
Jianhua MaFrom the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).ORCID 0000-0003-2958-1710
Changhai DingFrom the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).ORCID 0000-0002-9479-730X
Zhujiang Hospital · CNBoston University · USCleveland Clinic Lerner College of Medicine · USNanfang Hospital · CNThe University of Sydney · AUThird Affiliated Hospital of Southern Medical University · CNUniversity of Arizona · USUniversity of Tasmania · AU
Funding
DATA COORDINATING CENTER FOR THE OSTEOARTHRITIS INITIATIVEN01AR22258 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL · 2007 to 2011
$13.5MCLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVEN01AR22259 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI HOCHBERG, MARC C. · 2007 to 2011
$7.8MClinical Centers for the Osteoarthritis Initiative^Rhode IslandN01AR22262 · NIAMS · MEMORIAL HOSPITAL OF RHODE ISLAND · PI EATON, CHARLES B. · 2007 to 2010
$6.8MCLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVEN01AR22261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH FDN · PI JACKSON, REBECCA · 2007 to 2011
$6.2MCLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVEN01AR22260 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2007 to 2010
$6.1MNHLBI NIH HHS N01AR22258NIAMS NIH HHS N01AR22259NIAMS NIH HHS N01AR22260NIAMS NIH HHS N01AR22261NIAMS NIH HHS N01AR22262
Abstract
Background Infrapatellar fat pad (IPFP) quality has been implicated as a marker for predicting knee osteoarthritis (KOA); however, no valid quantification for subtle IPFP abnormalities has been established. Purpose To investigate whether MRI-based three-dimensional texture analysis of IPFP abnormalities could help predict incident radiographic KOA. Materials and Methods In this prospective nested case-control study, 690 participants whose knees were at risk for KOA were included from the Pivotal Osteoarthritis Initiative MRI Analyses incident osteoarthritis cohort. All knees had a Kellgren-Lawrence grade of 1 or less at baseline. During the 4-year follow-up, case participants were matched 1:1 to control participants, with incident radiographic KOA as the outcome. MRI scans were segmented at the incident time point of KOA (hereafter, P0), 1 year before P0 (hereafter, P-1), and baseline. MRI-based three-dimensional texture analysis was performed to extract IPFP texture features. Least absolute shrinkage and selection operator and multivariable logistic regressions were applied in the development cohort and evaluated in the test cohort. The area under the receiver operating characteristic curve (AUC) was used to evaluate the discriminative value of the clinical score, IPFP texture score, and MRI Osteoarthritis Knee Score. Results Participants were allocated to development (
Indexed as
Osteoarthritis, KneeAdipose TissueCase-Control StudiesFemaleHumansIncidenceKnee JointMagnetic Resonance ImagingMaleMiddle AgedProspective Studies
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