ArticleRadiology2022
Traction Bronchiectasis/Bronchiolectasis on CT Scans in Relationship to Clinical Outcomes and Mortality: The COPDGene Study.
Open access · greenAbstract read
In one paragraph
Article in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
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- Survival impact of fibrotic interstitial lung abnormalities in resected stage IA non-small cell lung cancer.The British journal of radiology · 2023Article
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- Traction Bronchiectasis/Bronchiolectasis in Interstitial Lung Abnormality: Follow-up in the COPDGene Study.American journal of respiratory and critical care medicine · 2023Article
- Traction bronchiectasis: is it as benign as we think?Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2022Article
Corrections and comments
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Authors and funding
25 authors at 9 institutions in 3 countries.
Akinori HataFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).ORCID 0000-0003-1149-7094
Takuya HinoFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).ORCID 0000-0002-8225-0737
Rachel K PutmanFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).
Masahiro YanagawaFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).ORCID 0000-0002-0911-6769
Tomoyuki HidaFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).
Aravind A MenonFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).ORCID 0000-0002-0211-4509
Osamu HondaFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).
Yoshitake YamadaFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).ORCID 0000-0002-5842-5349
Mizuki NishinoFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).ORCID 0000-0003-0275-0502
Tetsuro ArakiFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).ORCID 0000-0003-0440-6078
Vladimir I ValtchinovFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).ORCID 0000-0002-3272-4826
Masahiro JinzakiFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).
Hiroshi HondaFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).
Kousei IshigamiFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).ORCID 0000-0001-8107-5570
Takeshi JohkohFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).
Noriyuki TomiyamaFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).ORCID 0000-0001-9918-7327
David C ChristianiFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).ORCID 0000-0002-0301-0242
David A LynchFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).ORCID 0000-0002-6329-2325
Raúl San José EstéparFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).ORCID 0000-0002-3677-1996
George R WashkoFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).
Michael H ChoFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).ORCID 0000-0002-4907-1657
Edwin K SilvermanFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).ORCID 0000-0002-3641-3822
Gary M HunninghakeFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).
Hiroto HatabuFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).ORCID 0000-0003-1436-2988
COPDGene InvestigatorsFrom the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).
Brigham and Women's Hospital · USHCL Technologies (India) · INKeio University · JPKyushu University · JPHarvard University · USHospital of the University of Pennsylvania · USKansai Medical University · JPKansai Rosai Hospital · JPNational Jewish Health · US
Funding
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7MThe Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2MClinical Genetics and Screening for Pulmonary FibrosisR01HL130974 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GARY MATTHEW HUNNINGHAKE, Benjamin Alexander Raby · 2016 to 2026
$10.0MGenetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung AbnormalitiesR01HL135142 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL H. CHO, GARY MATTHEW HUNNINGHAKE · 2017 to 2026
$7.7MInterstitial Lung Abnormalities: Defining the Phenotype, Causes, and Consequences.R01HL111024 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HUNNINGHAKE, GARY MATTHEW · 2013 to 2022
$6.4MThe clinical impact of pulmonary vascular remodeling in smokersR01HL116473 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAN JOSE ESTEPAR, RAUL, WASHKO, GEORGE R · 2013 to 2021
$5.0MGenetic and Functional Dissection of a Cluster of COPD GWAS Signals on Chromosome 4qR01HL147148 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2019 to 2022
$3.5MIdentifying functional variants in COPD GWAS lociR01HL137927 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2017 to 2020
$3.5MClinical Implications, Genomics, and Transcriptions of Mucus Plugging in SmokersR01HL149861 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., DIAZ, ALEJANDRO · 2020 to 2023
$3.2MAutomated in vivo analysis of tumor growth rate as a guide for therapeutic decisions to advance personalized cancer treatmentR01CA203636 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI NISHINO, MIZUKI · 2017 to 2021
$2.9MPrognostic Markers of Emphysema ProgressionR01HL149877 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAN JOSE ESTEPAR, RAUL · 2020 to 2023
$2.8MNCI NIH HHS R01 CA203636NCI NIH HHS R01 CA240592NCI NIH HHS U01 CA209414NHLBI NIH HHS K08 HL140087NHLBI NIH HHS R01 HL111024NHLBI NIH HHS R01 HL116473NHLBI NIH HHS R01 HL122464NHLBI NIH HHS R01 HL130974NHLBI NIH HHS R01 HL135142NHLBI NIH HHS R01 HL137927NHLBI NIH HHS R01 HL147148NHLBI NIH HHS R01 HL149861NHLBI NIH HHS R01 HL149877NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897
Abstract
Background The clinical impact of interstitial lung abnormalities (ILAs) on poor prognosis has been reported in many studies, but risk stratification in ILA will contribute to clinical practice. Purpose To investigate the association of traction bronchiectasis/bronchiolectasis index (TBI) with mortality and clinical outcomes in individuals with ILA by using the COPDGene cohort. Materials and Methods This study was a secondary analysis of prospectively collected data. Chest CT scans of participants with ILA for traction bronchiectasis/bronchiolectasis were evaluated and outcomes were compared with participants without ILA from the COPDGene study (January 2008 to June 2011). TBI was classified as follows: TBI-0, ILA without traction bronchiectasis/bronchiolectasis; TBI-1, ILA with bronchiolectasis but without bronchiectasis or architectural distortion; TBI-2, ILA with mild to moderate traction bronchiectasis; and TBI-3, ILA with severe traction bronchiectasis and/or honeycombing. Clinical outcomes and overall survival were compared among the TBI groups and the non-ILA group by using multivariable linear regression model and Cox proportional hazards model, respectively. Results Overall, 5295 participants (median age, 59 years; IQR, 52-66 years; 2779 men) were included, and 582 participants with ILA and 4713 participants without ILA were identified. TBI groups were associated with poorer clinical outcomes such as quality of life scores in the multivariable linear regression model (TBI-0: coefficient, 3.2 [95% CI: 0.6, 5.7;
Indexed as
BronchiectasisLung DiseasesHumansMaleMiddle AgedQuality of LifeTomography, X-Ray ComputedTraction
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