Evidence map›Paper›PMID 35638781›Full record

ArticleMicrobiology spectrum2022

Cardiolipin Biosynthesis Genes Are Not Required for

Melina B Cian, Joshua A Mettlach, Aaron E Zahn, Nicole P Giordano, Keaton E Minor, Michael McClelland, Zachary D Dalebroux

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Fenofibrate suppressesFrontiers in cellular and infection microbiology · 2025
    Article
  4. A Lipid Perspective on Regulated Pyroptosis.International journal of biological sciences · 2023
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Melina B CianDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Centergrid.266902.9, Oklahoma City, Oklahoma, USA.
Joshua A MettlachDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Centergrid.266902.9, Oklahoma City, Oklahoma, USA.
Aaron E ZahnDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Centergrid.266902.9, Oklahoma City, Oklahoma, USA.
Nicole P GiordanoDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Centergrid.266902.9, Oklahoma City, Oklahoma, USA.
Keaton E MinorDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Centergrid.266902.9, Oklahoma City, Oklahoma, USA.
Michael McClellandDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, California, USA.
Zachary D DalebrouxDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Centergrid.266902.9, Oklahoma City, Oklahoma, USA.ORCID 0000-0001-9348-2894
University of Oklahoma Health Sciences Center · USUniversity of California, Irvine · US

Funding

Proteomics CoreP20GM103447 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Mark L Lang · 2012 to 2026
$60.2M
Molecular Basis of Immunity - Kirschtein-NRSAT32AI007633 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CUNNINGHAM, MADELEINE W. · 2001 to 2022
$4.0M
Molecular determinants of oxidative stress in Salmonella pathogenesisR01AI136520 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Andres Vazquez-Torres · 2018 to 2026
$3.7M
Mechanisms of PbgA involvement in Salmonella Typhimurium lipid homeostasis for bacterial pathogenesisR01AI139248 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI DALEBROUX, ZACHARY DAVID · 2018 to 2022
$1.8M
Barcoding a Salmonella gene knockout libraryR03AI139557 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI MCCLELLAND, MICHAEL · 2019 to 2020
$157k
NIAID NIH HHS R01 AI136520NIAID NIH HHS R01 AI139248NIAID NIH HHS R03 AI139557NIAID NIH HHS T32 AI007633NIGMS NIH HHS P20 GM103447
6 · The paper itself

Abstract

Salmonella enterica serovar Typhimurium is an intracellular pathogen that parasitizes macrophages from within a vacuole. The vacuolar environment prompts the bacterium to regulate the lipid composition of the outer membrane (OM), and this influences host inflammation.

Indexed as

Salmonella entericaSalmonella typhimuriumAnimalsCardiolipinsInflammasomesInflammationLipopolysaccharidesMiceMice, Inbred C57BLSerogroupToll-Like Receptor 4CardiolipinsInflammasomesLipopolysaccharidesToll-Like Receptor 4bacteremiacardiolipinClsAClsBClsCgastroenteritisinflammasomeinterleukin-1 betainterleukinslipopolysaccharidemacrophagephospholipase-DphospholipidspyroptosisToll-like receptor fourtumor necrosis factor alpha

Identifiers

PMID35638781
PMCPMC9241728
OpenAlexW4281785954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.