Evidence map›Paper›PMID 35638778›Full record

ArticleMicrobiology spectrum2022

Genome Evolution of Invasive Methicillin-Resistant Staphylococcus aureus in the Americas.

Joshua T Smith, Elissa M Eckhardt, Nicole B Hansel, Tahmineh Rahmani Eliato, Isabella W Martin, Cheryl P Andam

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Co-occurrence of blaBMC microbiology · 2026
    Article
  2. Population genomic variation inMicrobial genomics · 2026
    Article
  3. Article
  4. Dynamic Networks of Methicillin-ResistantOpen forum infectious diseases · 2025
    Article
  5. Article
  6. Article
  7. Methicillin-resistantFrontiers in microbiology · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Demographic fluctuations in bloodstreamnpj antimicrobials and resistance · 2024
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Joshua T SmithDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, New Hampshire, USA.ORCID 0000-0001-5511-8717
Elissa M EckhardtDartmouth-Hitchcock Medical Center and Dartmouth College Geisel School of Medicine, Lebanon, New Hampshire, USA.
Nicole B HanselDartmouth-Hitchcock Medical Center and Dartmouth College Geisel School of Medicine, Lebanon, New Hampshire, USA.
Tahmineh Rahmani EliatoDepartment of Chemical Engineering, University of New Hampshire, Durham, New Hampshire, USA.ORCID 0000-0001-7316-0222
Isabella W MartinDartmouth-Hitchcock Medical Center and Dartmouth College Geisel School of Medicine, Lebanon, New Hampshire, USA.
Cheryl P AndamDepartment of Biological Sciences, University at Albany, State University of New Yorkgrid.265850.c, Albany, New York, USA.ORCID 0000-0003-4428-0924
Dartmouth College · USAlbany State University · USBroad Institute · USUniversity of New Hampshire · US

Funding

Population and evolutionary dynamics of recombining genes and alleles in bacteriaR35GM142924 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Cheryl Marie P Andam · 2021 to 2026
$1.9M
NIGMS NIH HHS R35 GM142924
6 · The paper itself

Abstract

Staphylococcus aureus causes a variety of debilitating and life-threatening diseases, and thus remains a challenging global health threat. S. aureus is remarkably diverse, yet only a minority of methicillin-resistant S. aureus (MRSA) clones have caused pandemic proportions of diseases. The genetic drivers of the successful dissemination of some clones across wide geographical expanses remain poorly understood. We analyzed 386 recently published MRSA genomes from bloodstream infections sampled in North, Central, and South America from 2011 to 2018. Here, we show that MRSA-associated bloodstream infections were attributable to two genetically distinct lineages. One lineage consisted almost exclusively of sequence type (ST) 8, which emerged in 1964. A second lineage emerged in 1986 and consisted of STs 5, 105, and 231. The two lineages have simultaneously disseminated across geographically distant sites. Sublineages rapidly diverged within locations in the early 2000s. Their diversification was associated with independent acquisitions of unique variants of the mobile

Indexed as

Methicillin-Resistant Staphylococcus aureusSepsisStaphylococcal InfectionsAmericasAnti-Bacterial AgentsEvolution, MolecularHumansStaphylococcus aureusAnti-Bacterial Agentsbloodstream infectiongenome evolutioninvasiveinvasive microorganismsmethicillin resistanceMRSAStaphylococcus aureus

Identifiers

PMID35638778
PMCPMC9241880
OpenAlexW4281669289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.