Evidence map›Paper›PMID 35638478›Full record

ArticleACS nano2022

Thermodynamic Size Control in Curvature-Frustrated Tubules: Self-Limitation with Open Boundaries.

Botond Tyukodi, Farzaneh Mohajerani, Douglas M Hall, Gregory M Grason, Michael F Hagan

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 33 citations in OpenAlex.

  1. From toroids to helical tubules: Kirigami-inspired programmable assembly of two-periodic curved crystals from DNA origami.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Designing the Self-Assembly of Disordered Materials Via Color Frustration.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  4. Article
  5. Article
  6. Limits of economy and fidelity for programmable assembly of size-controlled triply periodic polyhedra.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Geometrically programmed self-limited assembly of tubules using DNA origami colloids.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Article
  10. Article
  11. Tiling a tubule: how increasing complexity improves the yield of self-limited assembly.Journal of physics. Condensed matter : an Institute of Physics journal · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Botond TyukodiMartin Fisher School of Physics, Brandeis University, Waltham, Massachusetts 02454, United States.ORCID 0000-0001-6868-1234
Farzaneh MohajeraniMartin Fisher School of Physics, Brandeis University, Waltham, Massachusetts 02454, United States.ORCID 0000-0002-9340-3305
Douglas M HallDepartment of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003, United States.ORCID 0000-0003-2829-6272
Gregory M GrasonDepartment of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003, United States.ORCID 0000-0001-5479-9370
Michael F HaganMartin Fisher School of Physics, Brandeis University, Waltham, Massachusetts 02454, United States.ORCID 0000-0002-9211-2434
Brandeis University · USUniversity of Massachusetts Amherst · US

Funding

Computational modeling of viral capsid and bacterial microcompartment assemblyR01GM108021 · NIGMS · BRANDEIS UNIVERSITY · PI HAGAN, MICHAEL F · 2013 to 2021
$2.7M
NIGMS NIH HHS R01 GM108021
6 · The paper itself

Abstract

We use computational modeling to investigate the assembly thermodynamics of a particle-based model for geometrically frustrated assembly, in which the local packing geometry of subunits is incompatible with uniform, strain-free large-scale assembly. The model considers discrete triangular subunits that drive assembly toward a closed, hexagonal-ordered tubule, but have geometries that locally favor negative Gaussian curvature. We use dynamical Monte Carlo simulations and enhanced sampling methods to compute the free energy landscape and corresponding self-assembly behavior as a function of experimentally accessible parameters that control assembly driving forces and the magnitude of frustration. The results determine the parameter range where finite-temperature self-limiting assembly occurs, in which the equilibrium assembly size distribution is sharply peaked around a well-defined finite size. The simulations also identify two mechanisms by which the system can escape frustration and assemble to unlimited size, and determine the particle-scale properties of subunits that suppress unbounded growth.

Indexed as

dynamical Monte Carlofree energy calculationsgeometric frustrationparallel temperingprogrammable assemblyself-limited assemblyumbrella sampling

Identifiers

PMID35638478
PMCPMC10362403
OpenAlexW3197343937

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.