Evidence map›Paper›PMID 35638357›Full record

ArticlemSphere2022

Eukaryotic Initiation Factor 2α Kinases Regulate Virulence Functions, Stage Conversion, and the Stress Response in Entamoeba invadens.

Heather A Walters, Brenda H Welter, Harrison C Moss, Martha A Villano, Ronny Orobio-Hurtado, William J Sullivan, Lesly A Temesvari

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Heather A WaltersDepartment of Biological Sciences, Clemson Universitygrid.26090.3d, Clemson, South Carolina, USA.
Brenda H WelterDepartment of Biological Sciences, Clemson Universitygrid.26090.3d, Clemson, South Carolina, USA.
Harrison C MossDepartment of Biological Sciences, Clemson Universitygrid.26090.3d, Clemson, South Carolina, USA.
Martha A VillanoDepartment of Biological Sciences, Clemson Universitygrid.26090.3d, Clemson, South Carolina, USA.
Ronny Orobio-HurtadoDepartment of Biological Sciences, Clemson Universitygrid.26090.3d, Clemson, South Carolina, USA.
William J SullivanDepartment of Pharmacology and Toxicology, Indiana University School of Medicine Indianapolis, Indiana, USA.ORCID 0000-0003-1823-8642
Lesly A TemesvariDepartment of Biological Sciences, Clemson Universitygrid.26090.3d, Clemson, South Carolina, USA.ORCID 0000-0002-4154-8158
Clemson University · USIndiana University School of Medicine

Funding

The role of acetate fermentation in Entamoeba histolytica growth and infectionP20GM109094 · NIGMS · CLEMSON UNIVERSITY · PI MORRIS, MEREDITH T · 2016 to 2020
$10.4M
Translational Control of Encystation in the EntamoebaeR21AI108287 · NIAID · CLEMSON UNIVERSITY · PI SULLIVAN, WILLIAM J, TEMESVARI, LESLY A · 2015 to 2016
$423k
Stress Induced Control of Protein Translation in Entamoeba HistolyticaR03AI107950 · NIAID · CLEMSON UNIVERSITY · PI TEMESVARI, LESLY A · 2014 to 2015
$147k
NIAID NIH HHS R03 AI107950NIAID NIH HHS R21 AI108287NIGMS NIH HHS P20 GM109094
6 · The paper itself

Abstract

Entamoeba histolytica is a protozoan parasite that causes amoebic dysentery and liver abscess. This pathogen possesses a two-stage life cycle consisting of an environmentally stable cyst and a pathogenic amoeboid trophozoite. Since infection is acquired by ingestion of cysts from contaminated food and water, this parasite is prevalent in underdeveloped countries. A reptilian pathogen, Entamoeba invadens, which can encyst in culture, has long served as a surrogate to study stage conversion. In the host,

Indexed as

CystsEntamoebaEntamoeba histolyticaAnimalseIF-2 KinaseHumansLife Cycle StagesMammalsVirulenceWatereIF-2 KinaseWaterdysenteryeIF2 alphaencystationEntamoeba histolyticahost-parasite adhesionoxidative stressphagocytosisstress adaptationstress kinases

Identifiers

PMID35638357
PMCPMC9241534
OpenAlexW4281777511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.