Evidence map›Paper›PMID 35638091›Full record

ArticleEuropean urology open science2022

Variation in Molecularly Defined Prostate Tumor Subtypes by Self-identified Race.

Kevin H Kensler, Shivanshu Awasthi, Mohamed Alshalalfa, Bruce J Trock, Stephen J Freedland, Michael R Freeman, Sungyong You, Brandon A Mahal, Robert B Den, Adam P Dicker and 8 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European urology open science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02609269 (Prospective Expression Analysis Using The Decipher Genomics Resource for Intelligent Discovery), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02609269 enrolling by invitationnot on this map

Prospective Expression Analysis Using The Decipher Genomics Resource for Intelligent Discovery (GRID)® and Data Sharing Program

Typeobservational_patient_registrySponsorGenomeDx Biosciences CorpRan2015 to 2040Enrolled1,000,000ConditionsProstate Cancer, Bladder Cancer, Renal CancerArmsDecipher Cancer Classifier
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 11 institutions in 1 country.

Kevin H KenslerDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.
Shivanshu AwasthiDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Mohamed AlshalalfaDepartment of Radiation Oncology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Bruce J TrockJohns Hopkins Brady Urological Institute, Baltimore, MD, USA.
Stephen J FreedlandDivision of Urology, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Michael R FreemanDivision of Urology, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Sungyong YouDivision of Urology, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Brandon A MahalDepartment of Radiation Oncology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Robert B DenDepartment of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA.
Adam P DickerDepartment of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA.
R Jeffrey KarnesDepartment of Urology, Mayo Clinic, Rochester, MN, USA.
Eric A KleinGlickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
Priti LalDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Yang LiuDecipher Biosciences, Inc., San Diego, CA, USA.
Elai DavicioniDecipher Biosciences, Inc., San Diego, CA, USA.
Walter RayfordThe Urology Group, LLC, Memphis, TN, USA.
Kosj YamoahDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Timothy R RebbeckDivision of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.
Cedars-Sinai Medical Center · USCoherus BioSciences (United States) · USMoffitt Cancer Center · USThomas Jefferson University · USUniversity of Miami · USCleveland Clinic · USCornell University · USHarvard University · USMayo Clinic in Arizona · USRegional Urology · USUniversity of Pennsylvania · US

Funding

Contributions of tumor molecular subtypes to prostate cancer racial disparitiesR00CA245900 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI KENSLER, KEVIN HUGHES · 2021 to 2023
$689k
NCI NIH HHS R00 CA245900
6 · The paper itself

Abstract

Background: Socioeconomic and health care utilization factors are major drivers of prostate cancer (PC) mortality disparities in the USA; however, tumor molecular heterogeneity may also contribute to the higher mortality among Black men. Objective: To compare differences in PC subtype frequency and genomic aggressiveness by self-identified race. Design setting and participants: Five molecular subtype classifiers were applied for 426 Black and 762 White PC patients in the Decipher Genomics Resource Information Database (GRID). Outcome measurements and statistical analysis: Differences in subtype frequency and tumor genomic risk (Decipher score >0.6) by race were evaluated using χ Results and limitations: Subtype frequencies differed by race for four classifiers. Subtypes characterized by the presence of Conclusions: The frequency of PC molecular subtypes differed by self-identified race. Additional studies are required to evaluate whether our observations suggest differences in the tumor genomic risk of progression by self-identified race. Patient summary: We studied five classifiers that identify subtypes of prostate tumors and found that subtypes differed in frequency between Black and White patients. Further research is warranted to evaluate how differences in tumor subtypes may contribute to disparities in prostate cancer mortality.

Indexed as

Cancer disparitiesProstate cancerTumor subtypes

Identifiers

PMID35638091
PMCPMC9142751
OpenAlexW4224881375

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.