Evidence map›Paper›PMID 35637950›Full record

ArticleInternational journal of biological sciences2022

Sublytic C5b-9 Induces CCL3/4 Production and Macrophage Accumulation in Thy-1N Rats via PKC-α/p65/IRF-8 Axis.

Wenbo Wang, Baomei Qian, Chenhui Zhao, Mingyu Peng, Longfei Liu, Mengxiao Xie, Na Peng, Qingling He, Shuai Ying, Yufeng Zhu and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. An Ingenane-Type Diterpene fromInternational journal of molecular sciences · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Wenbo WangDepartment of Immunology, and Key Laboratory of Immunological Environment and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Baomei QianDepartment of Immunology, and Key Laboratory of Immunological Environment and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Chenhui ZhaoDepartment of Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Mingyu PengDepartment of Immunology, and Key Laboratory of Immunological Environment and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Longfei LiuDepartment of Immunology, and Key Laboratory of Immunological Environment and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Mengxiao XieDepartment of Immunology, and Key Laboratory of Immunological Environment and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Na PengDepartment of Rheumatology and Nephrology, The Second People's Hospital of China Three Gorges University, Yichang, China.
Qingling HeDepartment of Immunology, and Key Laboratory of Immunological Environment and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Shuai YingDepartment of Immunology, and Key Laboratory of Immunological Environment and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Yufeng ZhuClinical Medical Science of the First Clinical Medical College, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Tao WangDepartment of Nephrology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu 211100, China.
Dajun HuDepartment of Rheumatology and Nephrology, The Second People's Hospital of China Three Gorges University, Yichang, China.
Dan ZhaoDepartment of Immunology, and Key Laboratory of Immunological Environment and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Jing ZhangDepartment of Immunology, and Key Laboratory of Immunological Environment and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Yingwei WangDepartment of Immunology, and Key Laboratory of Immunological Environment and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Wen QiuDepartment of Immunology, and Key Laboratory of Immunological Environment and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Nanjing Medical University · CNChina Three Gorges University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesangioproliferative glomerulonephritis (MsPGN) is a common human kidney disease. Rat Thy-1 nephritis (Thy-1N) is an animal model widely used for the study of MsPGN. Thy-1N is not only sublytic C5b-9-dependent, but also related to pro-inflammatory cytokine production and macrophage (Mφ) accumulation in rat renal tissues. In this study, we found that the expression or phosphorylation of chemokine CCL3/4, CD68 (Mφ marker), IRF-8, PKC-α and NF-κB-p65 (p65) were all up-regulated both in the renal tissues of Thy-1N rats (

Indexed as

Complement Membrane Attack ComplexGlomerulonephritisMacrophagesAnimalsChemokine CCL3Chemokine CCL4HumansInterferon Regulatory Factor-8Interferon Regulatory FactorsProtein Kinase C-alphaRatsTranscription Factor RelAChemokine CCL3Chemokine CCL4Complement Membrane Attack ComplexInterferon Regulatory Factor-8Interferon Regulatory FactorsProtein Kinase C-alphaRela protein, ratTranscription Factor RelACCL3/4IRF-8macrophagemesangioproliferative glomerulonephritissublytic C5b-9Thy-1 nephritis

Identifiers

PMID35637950
PMCPMC9134925
OpenAlexW4285108643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.