Evidence map›Paper›PMID 35637946›Full record

ReviewInternational journal of biological sciences2022

Exosomes in atherosclerosis: Convergence on macrophages.

Kaiying Yang, Qi Xiao, Mengying Niu, Xudong Pan, Xiaoyan Zhu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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  18. Ribosome biogenesis in disease: new players and therapeutic targets.Signal transduction and targeted therapy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kaiying YangDepartment of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Qi XiaoDepartment of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Mengying NiuDepartment of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Xudong PanDepartment of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Xiaoyan ZhuDepartment of Critical Care Medicine, The Affiliated Hospital of Qingdao Universality, Qingdao, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the primary cells of atherosclerotic plaques, macrophages play a central role in the occurrence and progression of atherosclerosis (AS). In recent years, macrophages have received extensive attention as therapeutic targets. Exosomes, as natural nanoparticles, have high biocompatibility and strong targeting ability and have been widely studied as imaging agents and drug carriers. Studies on the relationship between atherosclerotic macrophages and exosomes have been focused on for the past few years. Nevertheless, no complex review has been undertaken in this area. In this review, we summarize in detail the role of macrophages in atherosclerosis, especially their plasticity and phenotypic and distributional heterogeneity. Based on the high correlation between macrophages and the pathological process of atherosclerosis, as well as the targeting of exosomes, we further review the clinical application of targeting macrophage-associated exosomes. We focus on the role of macrophage-associated exosomes in the phenotypic transformation of cells in atherosclerosis, providing a new idea for the clinical application of targeting macrophage-associated exosomes. Finally, we specifically summarize and prospect the diagnosis of macrophage-associated exosomes, such as imaging agent delivery, biomarkers and therapeutic strategies.

Indexed as

AtherosclerosisExosomesPlaque, AtheroscleroticHumansLeukocyte CountMacrophagesAtherosclerosisBiomaterialsExosomesExtracellular vesiclesMacrophage

Identifiers

PMID35637946
PMCPMC9134907

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.