Evidence map›Paper›PMID 35637730›Full record

ArticleiScience2022

A global method for fast simulations of molecular dynamics in multiscale agent-based models of biological tissues.

Daniel Bergman, Randy F Sweis, Alexander T Pearson, Fereshteh Nazari, Trachette L Jackson

Abstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel BergmanDepartment of Mathematics, University of Michigan, Ann Arbor, MI 48109, USA.
Randy F SweisDepartment of Medicine, Section of Hematology/Oncology, The University of Chicago, 5841 S Maryland Avenue, MC 2115, Chicago, IL 60605, USA.
Alexander T PearsonDepartment of Medicine, Section of Hematology/Oncology, The University of Chicago, 5841 S Maryland Avenue, MC 2115, Chicago, IL 60605, USA.
Fereshteh NazariApplied BioMath, LLC, Concord, MA 01742, USA.
Trachette L JacksonDepartment of Mathematics, University of Michigan, Ann Arbor, MI 48109, USA.

Funding

Multiscale Computational Models Guided By Emerging Cellular Dynamics Quantification For Predicting Optimum Immune Checkpoint And Targeted Therapy SchedulesU01CA243075 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACKSON, TRACHETTE · 2020 to 2024
$2.6M
Elucidating immunotherapy resistance mechanisms in non-T cell-inflamed bladder cancerK08CA234392 · NCI · UNIVERSITY OF CHICAGO · PI SWEIS, RANDY F. · 2018 to 2021
$851k
NCI NIH HHS K08 CA234392NCI NIH HHS U01 CA243075
6 · The paper itself

Abstract

Agent-based models (ABMs) are a natural platform for capturing the multiple time and spatial scales in biological processes. However, these models are computationally expensive, especially when including molecular-level effects. The traditional approach to simulating this type of multiscale ABM is to solve a system of ordinary differential equations for the molecular events per cell. This significantly adds to the computational cost of simulations as the number of agents grows, which contributes to many ABMs being limited to around

Indexed as

In silico biologyMathematical biosciencesSystems biology

Identifiers

PMID35637730
PMCPMC9142654

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.