Evidence map›Paper›PMID 35637615›Full record

Trial reportPalliative medicine2022

Acceptance and commitment therapy for patient fatigue interference and caregiver burden in advanced gastrointestinal cancer: Results of a pilot randomized trial.

Catherine E Mosher, Ekin Secinti, Wei Wu, Deborah A Kashy, Kurt Kroenke, Jonathan B Bricker, Paul R Helft, Anita A Turk, Patrick J Loehrer, Amikar Sehdev and 3 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Palliative medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04010227 (Telephone Support for Advanced Gastrointestinal Cancer Patients and Their Family Caregivers), which is not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04010227 nacompletednot on this map

Telephone Support for Advanced Gastrointestinal Cancer Patients and Their Family Caregivers

TypeinterventionalSponsorIndiana UniversityRan2019 to 2021Enrolled84ConditionsGastrointestinal NeoplasmsArmsAcceptance and Commitment Therapy, Education/Support
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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  6. Randomized Controlled Trial of Acceptance and Commitment Therapy for Fatigue Interference With Functioning in Metastatic Breast Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
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  8. Adopting a couples' approach to treating chronic cancer-related fatigue: a single-arm pilot trial of a web-based cognitive therapy for couples.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Catherine E MosherDepartment of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.ORCID 0000-0002-9689-5392
Ekin SecintiDepartment of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
Wei WuDepartment of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
Deborah A KashyMichigan State University, East Lansing, MI, USA.
Kurt KroenkeDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Jonathan B BrickerDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Paul R HelftIndiana University School of Medicine, Indiana Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, USA.
Anita A TurkIndiana University School of Medicine, Indiana Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, USA.
Patrick J LoehrerIndiana University School of Medicine, Indiana Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, USA.
Amikar SehdevIndiana University School of Medicine, Indiana Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, USA.
Ahmad A Al-HaderIndiana University School of Medicine, Indiana Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, USA.
Victoria L ChampionIndiana University School of Nursing, Indianapolis, IN, USA.
Shelley A JohnsDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Indiana University Health · USUniversity of Indianapolis · USIndiana University – Purdue University Indianapolis · USIndiana University School of MedicineMichigan State University · USRegenstrief Institute · USUniversity of Washington · US

Funding

Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Samuel Joseph Endicott · 2017 to 2026
$24.9M
Acceptance and Commitment Therapy for Fatigue Interference in Advanced Gastrointestinal Cancer Patients and Caregiver BurdenR21CA235788 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI MOSHER, CATHERINE E · 2019 to 2020
$384k
NCI NIH HHS R21 CA235788NIGMS NIH HHS P20 GM121176
6 · The paper itself

Abstract

backgroundFatigue often interferes with functioning in patients with advanced cancer, resulting in increased family caregiver burden. Acceptance and commitment therapy, a promising intervention for cancer-related suffering, has rarely been applied to dyads coping with advanced cancer.

aimTo examine the feasibility, acceptability, and preliminary efficacy of acceptance and commitment therapy for patient-caregiver dyads coping with advanced gastrointestinal cancer. Primary outcomes were patient fatigue interference and caregiver burden.

designIn this pilot trial, dyads were randomized to six weekly sessions of telephone-delivered acceptance and commitment therapy or education/support, an attention control. Outcomes were assessed at baseline and at 2 weeks and 3 months post-intervention. SETTING/

participantsForty patients with stage III-IV gastrointestinal cancer and fatigue interference and family caregivers with burden or distress were recruited from two oncology clinics and randomized.

resultsThe eligibility screening rate (54%) and retention rate (81% at 2 weeks post-intervention) demonstrated feasibility. At 2 weeks post-intervention, acceptance and commitment therapy participants reported high intervention helpfulness (mean = 4.25/5.00). Group differences in outcomes were not statistically significant. However, when examining within-group change, acceptance and commitment therapy patients showed moderate decline in fatigue interference at both follow-ups, whereas education/support patients did not show improvement at either follow-up. Acceptance and commitment therapy caregivers showed medium decline in burden at 2 weeks that was not sustained at 3 months, whereas education/support caregivers showed little change in burden.

conclusionsAcceptance and commitment therapy showed strong feasibility, acceptability, and promise and warrants further testing.

trial registrationClinicalTrials.gov NCT04010227. Registered 8 July 2019, https://clinicaltrials.gov/ct2/show/NCT04010227?term=catherine+mosher&draw=2&rank=1.

Indexed as

Acceptance and Commitment TherapyGastrointestinal NeoplasmsCaregiver BurdenCaregiversFatigueHumansPilot ProjectsQuality of Lifeacceptance and commitment therapycaregiver burdenclinical trialfamily caregiversfatigueNeoplasmsquality of life

Identifiers

PMID35637615
PMCPMC9396957
OpenAlexW4281634502

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.