ArticleGenes & nutrition2022
Genetic support of a causal relationship between iron status and atrial fibrillation: a Mendelian randomization study.
Article in Genes & nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Iron Status and Risk of Heart Disease, Stroke, and Diabetes: A Mendelian Randomization Study in European Adults.Journal of the American Heart Association · 2024Pooled it
- Exploring genetic association of systemic iron status and risk with incidence of diabetic neuropathy.Diabetology & metabolic syndrome · 2024Article
- Iron deficiency and supplementation in heart failure.Nature reviews. Cardiology · 2024Review
- Associations Between Genetically Predicted Iron Status and Cardiovascular Disease Risk: A Mendelian Randomization Study.Journal of the American Heart Association · 2024Article
- Genetic Evidence for Causal Relationships between Plasma Eicosanoid Levels and Cardiovascular Disease.Metabolites · 2024Article
- High Dietary Intake of Iron Might Be Harmful to Atrial Fibrillation and Modified by Genetic Diversity: A Prospective Cohort Study.Nutrients · 2024Article
- Associations between genetically predicted iron status and cardiovascular disease risk: A Mendelian randomization study.medRxiv : the preprint server for health sciences · 2024Article
- Paroxysmal atrial fibrillation and hemochromatosis: a narrative review.Annals of medicine and surgery (2012) · 2024Review
- Using Mendelian Randomization to Study the Role of Iron in Health and Disease.International journal of molecular sciences · 2023Review
- Genetically supported causality between benign prostate hyperplasia and urinary bladder neoplasms: A mendelian randomization study.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAtrial fibrillation is the most common arrhythmia disease. Animal and observational studies have found a link between iron status and atrial fibrillation. However, the causal relationship between iron status and AF remains unclear. The purpose of this investigation was to use Mendelian randomization (MR) analysis, which has been widely applied to estimate the causal effect, to reveal whether systemic iron status was causally related to atrial fibrillation.
methodsSingle nucleotide polymorphisms (SNPs) strongly associated (P < 5 × 10
resultsGenetically instrumented serum iron [OR 1.09; 95% confidence interval (CI) 1.02-1.16; p = 0.01], ferritin [OR 1.16; 95% CI 1.02-1.33; p = 0.02], and transferrin saturation [OR 1.05; 95% CI 1.01-1.11; p = 0.01] had positive effects on atrial fibrillation. Genetically instrumented transferrin levels [OR 0.90; 95% CI 0.86-0.97; p = 0.006] were inversely correlated with atrial fibrillation.
conclusionIn conclusion, our results strongly elucidated a causal link between genetically determined higher iron status and increased risk of atrial fibrillation. This provided new ideas for the clinical prevention and treatment of atrial fibrillation.
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