ArticleNature cancer2022
Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors.
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Article in Nature cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 52 citations in OpenAlex.
- Cross-species transcriptomic integration reveals a MIRO1-mediated macrophage-T cell axis in glioma.Life science alliance · 2026Article
- Co-stimulatory signal deficiency impairs cytotoxic T lymphocyte function in tumor immune evasion: molecular mechanisms and therapeutic implications.Journal of translational medicine · 2026Review
- Roles of ADP-Ribosyltransferases in Cancer.Oncology research · 2026Review
- Targeting MARylation and DePARylation in Cancer Therapy: New Promising Therapeutic Opportunities.Cancers · 2025Review
- The Role of Immune Checkpoint Inhibitors in Cancer Therapy: Mechanism and Therapeutic Advances.MedComm · 2025Review
- Review
- Mono-ADP-ribosylating PARP enzymes in cellular signaling and disease.Journal of cell science · 2025Review
- Development and optimization of Eva1 (Journal for immunotherapy of cancer · 2025Article
- Tumor‑associated neutrophils: Critical regulators in cancer progression and therapeutic resistance (Review).International journal of oncology · 2025Review
- Immunocytes in the tumor microenvironment: recent updates and interconnections.Frontiers in immunology · 2025Review
- Expanding the horizon of CAR T cell therapy: from cancer treatment to autoimmune diseases and beyond.Frontiers in immunology · 2025Review
- Exploration of the diagnostic and prognostic roles of decreased autoantibodies in lung cancer.Frontiers in immunology · 2025Article
- PARP enzymes and mono-ADP-ribosylation: advancing the connection from interferon-signalling to cancer biology.Expert reviews in molecular medicine · 2024Review
- Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies.Science translational medicine · 2024Article
- Pathological and physiological roles of ADP-ribosylation: established functions and new insights.Biological chemistry · 2024Review
- Expanding the Perspective on PARP1 and Its Inhibitors in Cancer Therapy: From DNA Damage Repair to Immunomodulation.Biomedicines · 2024Review
- PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies.Cell reports. Medicine · 2024Article
- ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity.Cell · 2024Article
- The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment.Nature communications · 2024Article
- Immunomodulatory roles of PARPs: Shaping the tumor microenvironment, one ADP-ribose at a time.Current opinion in chemical biology · 2023Review
Corrections and comments
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Authors and funding
27 authors at 5 institutions in 2 countries.
Hongru ZhangDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Pengfei YuDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3894-5697
Vivek S TomarDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Xiangjie ChenInstitutes of Biology and Medical Sciences and Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou, China.
Matthew J AthertonDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9830-3151
Zhen LuDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hong-Guang ZhangInstitutes of Biology and Medical Sciences and Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou, China.
Shifeng LiDept. of Intensive Care Medicine, First Affiliated Hospital of Soochow University, Suzhou, China.
Angelica OrtizDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jun GuiDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
N Adrian LeuDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Fangxue YanDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Andres BlancoDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mirella L Meyer-FiccaDepartment of Animal, Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences and School of Veterinary Medicine, Utah State University, Logan, UT, USA.ORCID http://orcid.org/0000-0002-9949-8157
Ralph G MeyerDepartment of Animal, Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences and School of Veterinary Medicine, Utah State University, Logan, UT, USA.
Daniel P BeitingDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jinyang LiDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Selene Nunez-CruzDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Roddy S O'ConnorDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lexus R JohnsonDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Andy J MinnDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Subin S GeorgeInstitute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Constantinos KoumenisDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
J Alan DiehlDepartment of Biochemistry, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0001-9854-5049
Michael C MiloneDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1580-9844
Hui ZhengInstitutes of Biology and Medical Sciences and Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou, China.ORCID http://orcid.org/0000-0002-4325-4946
Serge Y FuchsDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. syfuchs@upenn.edu.ORCID http://orcid.org/0000-0002-0136-5103
University of Pennsylvania · USSoochow University · CNUtah State University · USCase Western Reserve University · USFoundation Center · US
Funding
UPR, interferon signaling and tumorigenesisP01CA165997 · NCI · UNIVERSITY OF PENNSYLVANIA · PI WILEYTO, E. PAUL · 2013 to 2023
$10.9MTherapeutic implication of CD38 in CLLR01CA233790 · NCI · MAYO CLINIC JACKSONVILLE · PI CHINI, EDUARDO N · 2019 to 2023
$3.0MReactivation of type I interferon pathway to increase the efficacy of chemotherapyR01CA247803 · NCI · UNIVERSITY OF PENNSYLVANIA · PI FUCHS, SERGE Y · 2020 to 2024
$1.8MType I Interferon Pathway in Pancreatic AdenocarcinomaR01CA240814 · NCI · UNIVERSITY OF PENNSYLVANIA · PI FUCHS, SERGE Y · 2020 to 2024
$1.8MMolecular sensors for metabolic programming of the sperm epigenome and offspring physiologyR01HD103027 · NICHD · UTAH STATE UNIVERSITY · PI MEYER-FICCA, MIRELLA L · 2021 to 2025
$1.5MPrognostic and Therapeutic Implications of IFNAR1 Signaling on CAR T Cell Therapy for CancerK08CA252619 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ATHERTON, MATTHEW JOHN · 2021 to 2025
$768kNAD Metabolism in Male Reproductive AgingR56AG069745 · NIA · UTAH STATE UNIVERSITY · PI CHINI, EDUARDO N, MEYER-FICCA, MIRELLA L · 2020 to 2020
$381kVitamin B3 requirements of the TestisR15HD100970 · NICHD · UTAH STATE UNIVERSITY · PI MEYER, RALPH G · 2020 to 2020
$363kNCI NIH HHS K08 CA252619NCI NIH HHS P01 CA165997NCI NIH HHS R01 CA233790NCI NIH HHS R01 CA240814NCI NIH HHS R01 CA247803NIA NIH HHS R56 AG069745NICHD NIH HHS R01 HD103027NICHD NIH HHS R15 HD100970
Abstract
Evasion of antitumor immunity and resistance to therapies in solid tumors are aided by an immunosuppressive tumor microenvironment (TME). We found that TME factors, such as regulatory T cells and adenosine, downregulated type I interferon receptor IFNAR1 on CD8
Indexed as
NeoplasmsReceptors, Chimeric AntigenHumansImmunosuppression TherapyImmunotherapy, AdoptivePoly(ADP-ribose) PolymerasesTumor MicroenvironmentPoly(ADP-ribose) PolymerasesReceptors, Chimeric Antigen
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