Evidence map›Paper›PMID 35637352›Full record

ArticleNature immunology2022

Type 2 cytokines in the thymus activate Sirpα

Elise R Breed, Matouš Vobořil, Katherine M Ashby, Ryan J Martinez, Lily Qian, Haiguang Wang, Oscar C Salgado, Christine H O'Connor, Kristin A Hogquist

Open access · greenAbstract read
In one paragraph

Article in Nature immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Thymic Dendritic Cells Revisited.Immunological reviews · 2025
    Review
  11. Unexpected heterogeneity and tissue-specific properties of the thymic hematopoietic antigen-presenting cell network.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Review
  13. Review
  14. Sterile production of interferons in the thymus.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Elise R Breed *Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Matouš Vobořil *Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Katherine M AshbyDepartment of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Ryan J MartinezDepartment of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Lily QianDepartment of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Haiguang WangDepartment of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-5403-9179
Oscar C SalgadoDepartment of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Christine H O'ConnorResearch Informatics Solutions, Laboratory Medicine and Pathology Group, Minnesota Supercomputing Institute, Minneapolis, MN, USA.
Kristin A HogquistDepartment of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA. hogqu001@umn.edu.ORCID http://orcid.org/0000-0001-9963-5687
University of Minnesota Medical Center · USMinnesota Supercomputing Institute · US

Funding

Type I interferons in tolerance in the steady stateP01AI035296 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MUELLER, DANIEL L · 1993 to 2023
$31.1M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008244 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SHIMIZU, YOJI · 1988 to 2024
$13.6M
IMMUNOLOGY TRAINING PROGRAMT32AI007313 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Carla Rothlin · 1989 to 2026
$5.7M
TCR signal strength in thymic selectionR37AI039560 · NIAID · UNIVERSITY OF MINNESOTA · PI HOGQUIST, KRISTIN A. · 2012 to 2021
$3.7M
Contribution of antigen presenting cells to thymic negative selectionF30AI131483 · NIAID · UNIVERSITY OF MINNESOTA · PI BREED, ELISE R · 2017 to 2020
$151k
NIAID NIH HHS F30 AI131483NIAID NIH HHS P01 AI035296NIAID NIH HHS R37 AI039560NIAID NIH HHS T32 AI007313NIGMS NIH HHS T32 GM008244
6 · The paper itself

Abstract

The thymus contains a diversity of dendritic cells (DCs) that exist in defined locations and have different antigen-processing and -presenting features. This suggests that they play nonredundant roles in mediating thymocyte selection. In an effort to eliminate SIRPα

Indexed as

Clonal DeletionDendritic CellsAntigen PresentationCytokinesLymphocyte ActivationThymus GlandCytokines

Identifiers

PMID35637352
PMCPMC10037932
OpenAlexW4281675789

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.