Evidence map›Paper›PMID 35637284›Full record

ArticleScientific reports2022

SARS-CoV-2 RNA in exhaled air of hospitalized COVID-19 patients.

Lisa Kurver, Corné H van den Kieboom, Kjerstin Lanke, Dimitri A Diavatopoulos, Gijs J Overheul, Mihai G Netea, Jaap Ten Oever, Reinout van Crevel, Karin Mulders-Manders, Frank L van de Veerdonk and 7 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Lisa KurverDepartment of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Corné H van den KieboomLaboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, route 469, Nijmegen, 6525 GA, The Netherlands.
Kjerstin LankeDepartment of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Dimitri A DiavatopoulosLaboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, route 469, Nijmegen, 6525 GA, The Netherlands.
Gijs J OverheulDepartment of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Mihai G NeteaDepartment of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Jaap Ten OeverDepartment of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Reinout van CrevelDepartment of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Karin Mulders-MandersDepartment of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Frank L van de VeerdonkDepartment of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Heiman WertheimDepartment of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Jeroen SchoutenDepartment of Intensive Care Medicine, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Janette Rahamat-LangendoenDepartment of Medical Microbiology, Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Ronald P van RijDepartment of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Teun BousemaDepartment of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Arjan van Laarhoven *Department of Internal Medicine and Radboud Centre for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Marien I de Jonge *Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, route 469, Nijmegen, 6525 GA, The Netherlands. Marien.deJonge@radboudumc.nl.
Radboud University Medical Center · NLRadboud University Nijmegen · NLUniversity Medical Center · USRadboud Institute for Molecular Life Sciences · NLLife & Brain (Germany) · DE

Funding

ULTIMATER01AI145781 · NIAID · STICHTING RADBOUD UNIVERSITEIT · PI THWAITES, GUY, VAN CREVEL, REINOUT · 2019 to 2023
$4.4M
European Research Council 833247NIAID NIH HHS R01 AI145781NIH HHS R01AI145781
6 · The paper itself

Abstract

Knowledge about contagiousness is key to accurate management of hospitalized COVID-19 patients. Epidemiological studies suggest that in addition to transmission through droplets, aerogenic SARS-CoV-2 transmission contributes to the spread of infection. However, the presence of virus in exhaled air has not yet been sufficiently demonstrated. In pandemic situations low tech disposable and user-friendly bedside devices are required, while commercially available samplers are unsuitable for application in patients with respiratory distress. We included 49 hospitalized COVID-19 patients and used a disposable modular breath sampler to measure SARS-CoV-2 RNA load in exhaled air samples and compared these to SARS-CoV-2 RNA load of combined nasopharyngeal throat swabs and saliva. Exhaled air sampling using the modular breath sampler has proven feasible in a clinical COVID-19 setting and demonstrated viral detection in 25% of the patients.

Indexed as

COVID-19RNA, ViralHumansNasopharynxPharynxSARS-CoV-2RNA, Viral

Identifiers

PMID35637284
PMCPMC9151771
OpenAlexW4281764913

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.