ArticleScientific reports2022
Competition between Pseudomonas aeruginosa and Staphylococcus aureus is dependent on intercellular signaling and regulated by the NtrBC two-component system.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 21 citations in OpenAlex.
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- Exploring microorganism-host interactions: Emerging organoid models and analytical approaches.mLife · 2026Review
- Coexistence with Staphylococcus aureus modulates the virulence and antibiotic resistance of Pseudomonas aeruginosa.Annals of clinical microbiology and antimicrobials · 2026Article
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- Nitric oxide tunes secreted metabolite bioactivity.bioRxiv : the preprint server for biology · 2025Article
- Characterizing interactions of Staphylococcus aureus and Escherichia coli in dual-species implant-associated biofilms.NPJ biofilms and microbiomes · 2025Article
- Gut Dysbiosis Driven byGenes · 2025Review
- Vancomycin Sensitization inACS infectious diseases · 2025Article
- Anti-QS Strategies AgainstMicroorganisms · 2025Review
- Toroidal displacement ofmBio · 2025Article
- Decoding Microbial Plastic Colonisation: Multi-Omic Insights Into the Fast-Evolving Dynamics of Early-Stage Biofilms.Proteomics · 2025Article
- Identification of the Pseudomonas aeruginosa AgtR-CspC-RsaL pathway that controls Las quorum sensing in response to metabolic perturbation and Staphylococcus aureus.PLoS pathogens · 2025Article
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- Polymicrobial infection in cystic fibrosis and future perspectives for improving Mycobacterium abscessus drug discovery.npj antimicrobials and resistance · 2024Review
- Synthesis of Bodipy-Tagged Galactoconjugates and Evaluation of Their Antibacterial Properties.Molecules (Basel, Switzerland) · 2024Article
- NorA efflux pump mediatesAntimicrobial agents and chemotherapy · 2024Article
- Competition of SARS-CoV-2 variants on the pandemic transmission dynamics.Chaos, solitons, and fractals · 2023Article
- Bacteriostatic and Antibiofilm Efficacy of a Nisin Z Solution against Co-Cultures ofLife (Basel, Switzerland) · 2023Article
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4 authors at 1 institution in 1 country.
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Abstract
Pseudomonas aeruginosa and Staphylococcus aureus are often comorbid human pathogens, isolated from expectorated sputum of cystic fibrosis patients and chronically infected wounds. Prior studies revealed a competitive advantage of P. aeruginosa over S. aureus in vitro that was slightly muted in vivo. Here, we demonstrated that the two-component regulatory system NtrBC influences the competitive advantage of P. aeruginosa over S. aureus in skin organoid and mouse models of co-infection. Expression of ntrBC was induced during co-culture of the two species and could be recapitulated in monoculture by the addition of the metabolite N-acetylglucosamine that is released from S. aureus following lysis. P. aeruginosa LESB58 WT, but not mutant (ΔntrC and ΔntrBC) strains, induced lysis of S. aureus USA300 LAC during planktonic growth and outcompeted S. aureus USA300 LAC during biofilm formation in vitro. We confirmed these findings in a murine abscess model of high-density infection. Accordingly, the secretory profile of P. aeruginosa LESB58 mutants revealed reduced production of anti-staphylococcal virulence factors including pyoverdine, pyocyanin and elastase. These phenotypes of LESB58 ΔntrBC could be at least partly complemented by overexpression of quorum sensing molecules including homoserine lactones or alkylquinolone signaling molecules. These data implicate the NtrBC two-component system in the complex regulatory cascade triggered by interspecies signaling that gives P. aeruginosa LESB58 a competitive edge over S. aureus USA300 LAC.
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