ArticleImmunity2022
BCL6-dependent TCF-1
Open access · greenAbstract read
In one paragraph
Article in Immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 75 citations in OpenAlex.
- Investigating CD8 T Cell Exhaustion in Chronic LCMV Infection by Flow Cytometry.Current protocols · 2026Article
- Lymphocyte-mediated immune responses to Leishmania infection.Nature reviews. Immunology · 2026Review
- Progenitor T cells drive chronic pulmonary type 2 inflammation.Nature immunology · 2026Article
- Clonal sharing and plasticity of follicular CD4 + T cells across lymph nodes and tumors in non-small cell lung cancer.Nature communications · 2026Article
- Reduced Tumor Control in Males Can Result from Impaired CD4+ T-cell Help through the CD40L-CD40 Pathway.Cancer immunology research · 2026Article
- Article
- Tissue-restricted secondary TCR engagement drives the transition from stem-like to CD200Nature immunology · 2026Article
- The MEK1/2-IRF4 axis fosters T follicular helper cell differentiationand antitumor humoral immune response.Journal of translational medicine · 2026Article
- High efficiency CRISPR knock-in demonstrates that TCF1 is insufficient to reverse T cell exhaustion.Nature communications · 2026Article
- Stepwise differentiation from precursor intermediates and distinct Th1 checkpoints promote CD4 Th1 cell differentiation during chronic viral infection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Regulators of CD8Nature reviews. Immunology · 2026Review
- Light Metabolically Reprograms CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Follicular T cells in the ovarian cancer immune microenvironment: biological insights and translational implications.Frontiers in immunology · 2026Review
- Stem-like CD4 T cells in tumors: an emerging framework for antitumor immunity.Frontiers in immunology · 2026Review
- EomesoderminImmunity · 2025Article
- Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells.bioRxiv : the preprint server for biology · 2025Article
- Selective expansion of TCF7-expressing tumor-reactive T cell subpopulations during ovarian tumor-infiltrating T cell production ex vivo.Science China. Life sciences · 2025Article
- Beyond T-cell subsets: stemness and adaptation redefining immunity and immunotherapy.Cellular & molecular immunology · 2025Review
- Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection.The Journal of experimental medicine · 2025Article
- T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses.The EMBO journal · 2025Article
Corrections and comments
- Commented on byCD42022
Authors and funding
16 authors at 3 institutions in 1 country.
Yu XiaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Katalin SandorDepartment of Pathology, Stanford University, Stanford, CA 94305, USA; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA.
Joy A PaiDepartment of Pathology, Stanford University, Stanford, CA 94305, USA; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA.
Bence DanielDepartment of Pathology, Stanford University, Stanford, CA 94305, USA; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA.
Saravanan RajuDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Renee WuDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Sunnie HsiungDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yanyan QiDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Tenzin YangdonDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mariko OkamotoDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Chun ChouDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kamir J Hiam-GalvezDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Robert D SchreiberDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kenneth M MurphyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ansuman T SatpathyDepartment of Pathology, Stanford University, Stanford, CA 94305, USA; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA. Electronic address: satpathy@stanford.edu.
Takeshi EgawaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: egawat@wustl.edu.
Washington University in St. Louis · USGladstone Institutes · USStanford University · US
Funding
MOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0MWashington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Alfred Hyoungju Kim · 2018 to 2026
$7.6MThe transcription factor c-MYC in lymphocyte expansion and restriction of stemnessR01AI130152 · NIAID · WASHINGTON UNIVERSITY · PI Takeshi Egawa · 2017 to 2026
$4.6M4DN Interrogation of T Cell Exhaustion in CancerU01CA260852 · NCI · STANFORD UNIVERSITY · PI SATPATHY, ANSUMAN · 2020 to 2024
$2.6MDEVELOPMENT OF GENOMICS BASED PERSONALIZED CANCER IMMUNOTHERAPYR01CA190700 · NCI · WASHINGTON UNIVERSITY · PI SCHREIBER, ROBERT DAVID · 2015 to 2019
$2.1MSingle cell epigenomics in cancer immunity and immunotherapyK08CA230188 · NCI · STANFORD UNIVERSITY · PI SATPATHY, ANSUMAN · 2018 to 2020
$448kIdentification of progenitor CD4 T cells that support response to chronic antigenR21AI161040 · NIAID · WASHINGTON UNIVERSITY · PI EGAWA, TAKESHI · 2021 to 2022
$433kTHE ROLE OF TH1 CD4 T CELLS IN CONTROL OF VIRAL INFECTIONR03AI139875 · NIAID · WASHINGTON UNIVERSITY · PI EGAWA, TAKESHI · 2018 to 2019
$156kThe role of type 1 dendritic cells in CD4 and CD8 T cell anti-tumor immunityF30CA247262 · NCI · WASHINGTON UNIVERSITY · PI WU, RENEE PAULA · 2021 to 2023
$117kNCI NIH HHS F30 CA247262NCI NIH HHS K08 CA230188NCI NIH HHS R01 CA190700NCI NIH HHS U01 CA260852NIAID NIH HHS R01 AI130152NIAID NIH HHS R03 AI139875NIAID NIH HHS R21 AI161040NIAID NIH HHS T32 AI007290NIAMS NIH HHS P30 AR073752
Abstract
Soon after activation, CD4
Indexed as
AntigensT-Lymphocytes, Helper-InducerAdoptive TransferAnimalsCell DifferentiationMiceProto-Oncogene Proteins c-bcl-6Stem CellsAntigensBcl6 protein, mouseProto-Oncogene Proteins c-bcl-6anti-tumor immunityCD4(+) T cellschronic viral infectioneffector T cellsfollicular helper T cellsprogenitor cellssingle-cell genomics
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.