Evidence map›Paper›PMID 35637088›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2022

Symptom Severity Mixity in Older-Age Bipolar Disorder: Analyses From the Global Aging and Geriatric Experiments in Bipolar Disorder Database (GAGE-BD).

Lisa T Eyler, Farren B S Briggs, Annemiek Dols, Soham Rej, Osvaldo P Almeida, Alexandra J M Beunders, Hilary P Blumberg, Brent P Forester, Regan E Patrick, Orestes V Forlenza and 10 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. The spectrum of bipolar disorder in older adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 15 institutions in 8 countries.

Lisa T EylerDepartment of Psychiatry (LTE), University of California San Diego, San Diego, CA; Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System (LTE), San Diego, CA. Electronic address: lteyler@health.ucsd.edu.
Farren B S BriggsDepartment of Population and Quantitative Health Sciences (FBSB), Case Western Reserve University School of Medicine, Cleveland, OH.
Annemiek DolsGGZ inGeest, Amsterdam UMC, VU Medical Center, Amsterdam Public Health Research Institute (AD, AJMB, SS, NPGP), Amsterdam, the Netherlands; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program and Neurodegeneration program, Amsterdam, the Netherlands.
Soham RejAmsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program and Neurodegeneration program, Amsterdam, the Netherlands.
Osvaldo P AlmeidaUniversity of Western Australia (OPA), Perth, Australia.
Alexandra J M BeundersGGZ inGeest, Amsterdam UMC, VU Medical Center, Amsterdam Public Health Research Institute (AD, AJMB, SS, NPGP), Amsterdam, the Netherlands.
Hilary P BlumbergDepartment of Psychiatry (HPB), Yale School of Medicine, New Haven, CT.
Brent P ForesterDivision of Geriatric Psychiatry (BPF), McLean Hospital, Belmont, MA; Harvard Medical School (BPF, REP), Boston, MA.
Regan E PatrickHarvard Medical School (BPF, REP), Boston, MA; Division of Geriatric Psychiatry (REP), McLean Hospital, Belmont, MA.
Orestes V ForlenzaLaboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry (OVF), HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Ariel GildengersDepartment of Psychiatry (AG), University of Pittsburgh School of Medicine, Pittsburgh, PA.
Esther JimenezBipolar and Depressive Disorders Unit, Hospital Clinic (EJ, EV), University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Eduard VietaBipolar and Depressive Disorders Unit, Hospital Clinic (EJ, EV), University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Benoit H MulsantDepartment of Psychiatry (BHM), University of Toronto, Center for Addiction & Mental Health, Toronto, Canada.
Sigfried SchouwsGGZ inGeest, Amsterdam UMC, VU Medical Center, Amsterdam Public Health Research Institute (AD, AJMB, SS, NPGP), Amsterdam, the Netherlands; GGZ inGeest, Amsterdam UMC (SS), VU Medical Center, Amsterdam, the Netherlands.
Nadine P G PaansGGZ inGeest, Amsterdam UMC, VU Medical Center, Amsterdam Public Health Research Institute (AD, AJMB, SS, NPGP), Amsterdam, the Netherlands; GGZ inGeest, Amsterdam UMC, VU Medical Center, Amsterdam Public Health Research Institute (NPGP), Amsterdam, the Netherlands.
Sergio StrejilevichAREA, Assistance and Research in Affective Disorders (SS), Buenos Aires, Argentina.
Ashley SutherlandDepartment of Psychiatry (AS), University of California San Diego, San Diego, CA.
Shangying TsaiDepartment of Psychiatry, School of Medicine (ST), College of Medicine, Taipei Medical University, Taipei, Taiwan.
Martha SajatovicCase Western Reserve University School of Medicine (MS), University Hospitals Cleveland Medical Center, Cleveland, OH.
GGZ inGeest · NLHarvard University · USUniversitat de Barcelona · ESUniversity of California, San Diego · USAmsterdam Neuroscience · NLAmsterdam University Medical Centers · NLCase Western Reserve University · USCentre for Addiction and Mental Health · CAHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRInstituto de Neurología Cognitiva · ARTaipei Medical University · TWUniversity of Pittsburgh · USUniversity of Western Australia · AUUniversity School · USYale University · US

Funding

Research Education ComponentP30AG066468 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI C. Elizabeth Shaaban · 2020 to 2026
$29.4M
Urban Revitalization and Long-Term Effects on Diet, Economic, and Health OutcomesR01CA149105 · NCI · RAND CORPORATION · PI DUBOWITZ, TAMARA · 2010 to 2021
$7.9M
Evaluation of Brain and Cognitive Changes in Older Adults with MCI Taking Lithium to Prevent Alzheimer Type DementiaR01AG055389 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GILDENGERS, ARIEL GERARD · 2017 to 2023
$5.4M
Genetics of Hippocampal Deficits in Bipolar DisorderR01MH070902 · NIMH · YALE UNIVERSITY · PI BLUMBERG, HILARY PATRICIA · 2005 to 2015
$5.1M
Aging and Emotion Regulation Brain Circuitry in Bipolar DisorderR01MH113230 · NIMH · YALE UNIVERSITY · PI BLUMBERG, HILARY PATRICIA · 2017 to 2021
$4.0M
Natural Experiment of Neighborhood Revitalization and Cardiometabolic HealthR01HL131531 · NHLBI · RAND CORPORATION · PI GARY-WEBB, TIFFANY L, TROXEL, WENDY M · 2016 to 2019
$3.0M
The Effects of Bipolar Disorder and its Comorbidities on Cognition in Older AdultR01MH084921 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GILDENGERS, ARIEL GERARD · 2010 to 2014
$1.8M
NCI NIH HHS R01 CA149105NHLBI NIH HHS R01 HL131531NIA NIH HHS P30 AG066468NIA NIH HHS R01 AG055389NIMH NIH HHS R01 MH070902NIMH NIH HHS R01 MH084921NIMH NIH HHS R01 MH113230
6 · The paper itself

Abstract

objectiveSome individuals with bipolar disorder (BD) experience manic and depressive symptoms concurrently, but data are limited on symptom mixity in older age bipolar disorder (OABD). Using the Global Aging & Geriatric Experiments in Bipolar Disorder Database, we characterized mixity in OABD and associations with everyday function.

methodsThe sample (n = 805), from 12 international studies, included cases with both mania and depression severity ratings at a single timepoint. Four mixity groups were created: asymptomatic (A), mixed (Mix), depressed only (Dep), and manic only (Man). Generalized linear mixed models used mixity group as the predictor variable; cohort was included as a random intercept. Everyday function was assessed with the Global Assessment of Functioning score.

resultsGroup proportions were Mix (69.6%; n = 560), followed by Dep (18.4%; n = 148), then A (7.8%; n = 63), then Man (4.2%; n= 34); levels of depression and mania were similar in Mix compared to Dep and Man, respectively. Everyday function was lowest in Mix, highest in A, and intermediate in Man and Dep. Within Mix, severity of depression was the main driver of worse functioning. Groups differed in years of education, with A higher than all others, but did not differ by age, gender, employment status, BD subtype, or age of onset.

conclusionsMixed features predominate in a cross-sectional, global OABD sample and are associated with worse everyday function. Among those with mixed symptoms, functional status relates strongly to current depression severity. Future studies should include cognitive and other biological variables as well as longitudinal designs to allow for evaluation of causal effects.

Indexed as

Bipolar DisorderAgedAgingCohort StudiesCross-Sectional StudiesHumansManiaBipolar disorderdepressionelderlygeriatricmania

Identifiers

PMID35637088
PMCPMC10280310
OpenAlexW4224281920

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.