Evidence map›Paper›PMID 35636931›Full record

ArticleSexually transmitted infections2023

Douching cessation and molecular bacterial vaginosis: a reanalysis of archived specimens.

Sarah Elizabeth Brown, Xin He, Michelle D Shardell, Jacques Ravel, Khalil G Ghanem, Jonathan M Zenilman, Rebecca M Brotman

Open access · greenAbstract read
In one paragraph

Article in Sexually transmitted infections, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sarah Elizabeth BrownInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-8354-0077
Xin HeDepartment of Epidemiology and Biostatistics, University of Maryland at College Park, College Park, Maryland, USA.
Michelle D ShardellInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Jacques RavelInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-0851-2233
Khalil G GhanemDivision of Infectious Diseases, Johns Hopkins Medicine School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-0033-302X
Jonathan M ZenilmanDivision of Infectious Diseases, Johns Hopkins Medicine School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-0244-6973
Rebecca M BrotmanInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA rbrotman@som.umaryland.edu.ORCID 0000-0001-8762-6214
University of Maryland, Baltimore · USJohns Hopkins University · USUniversity of Maryland, College Park · US

Funding

Lubricant Use and the Vaginal MicrobiomeR01AI119012 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BROTMAN, REBECCA M. · 2016 to 2020
$3.7M
Methods to Test the Role of Age-related Lifestyle and Vaginal Microenvironment Changes and the Prevention, Treatment, and Progression of Genitourinary Syndrome of MenopauseR01AG069915 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI REBECCA M. BROTMAN, Michelle Denise Shardell · 2021 to 2026
$3.1M
The Microbial Ecology of Bacterial Vaginosis: A Fine Scale Resolution MetagenomicUH2AI083264 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RAVEL, JACQUES · 2009 to 2011
$1.9M
Molecular Epidemiology of the Vaginal MicrobiomeK01AI080974 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BROTMAN, REBECCA M. · 2010 to 2014
$644k
Recovery of Vaginal Flora after Douching CessationR03AI061131 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ZENILMAN, JONATHAN M · 2005 to 2006
$125k
NIAID NIH HHS K01 AI080974NIAID NIH HHS R01 AI119012NIAID NIH HHS R03 AI061131NIAID NIH HHS UH2 AI083264NIA NIH HHS R01 AG069915
6 · The paper itself

Abstract

objectivesObservational studies demonstrate an association between vaginal douching and bacterial vaginosis (BV) characterised by Gram stain. We sought to describe the effect of a douching cessation intervention on the composition and structure of the vaginal microbiota and molecular-BV, a state defined by low levels of

methods33 women self-collected mid-vaginal swabs twice weekly (982 samples) during a douching observation phase (4 weeks) followed by a douching cessation phase (12 weeks) in a 2005 single crossover pilot study conducted in Baltimore, Maryland. Vaginal microbiota were characterised by

resultsThere was no statistically significant change in the odds of molecular-BV versus

conclusionsIn this pilot study, douching cessation was not associated with major changes in vaginal microbiota. Douching cessation alone may not durably shift the vaginal microbiota and additional interventions may be needed to restore optimal vaginal microbiota among those who douche.

Indexed as

Vaginosis, BacterialBacteriaFemaleHumansLactobacillusPilot ProjectsRNA, Ribosomal, 16STherapeutic IrrigationVaginaRNA, Ribosomal, 16SMICROBIOLOGYMOLECULAR EPIDEMIOLOGYREPRODUCTIVE HEALTHSexual BehaviourVaginosis, Bacterial

Identifiers

PMID35636931
PMCPMC9708945
OpenAlexW4281732575

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.