Evidence map›Paper›PMID 35636646›Full record

ArticleNeurobiology of disease2022

A Pitx3-deficient developmental mouse model for fine motor, olfactory, and gastrointestinal symptoms of Parkinson's disease.

Bin Song, Jacob W Feldmann, Shibo Cao, Melissa Feitosa, Youngbin Kong, Woori Kim, Altana Schweitzer, Pierre Leblanc, Jeffrey S Schweitzer, Kwang-Soo Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bin SongDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA; Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA; Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China. Electronic address: binsong@fudan.edu.cn.
Jacob W FeldmannDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Shibo CaoDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA; Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.
Melissa FeitosaDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA; Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.
Youngbin KongDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA; Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.
Woori KimDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA; Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.
Altana SchweitzerDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA; Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.
Pierre LeblancDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA; Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.
Jeffrey S SchweitzerDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Kwang-Soo KimDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA; Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA. Electronic address: kskim@mclean.harvard.edu.

Funding

Protein-induced human iPS cells for personalized cell therapy of PDR01NS070577 · NINDS · MCLEAN HOSPITAL · PI KIM, KWANG-SOO, KORDOWER, JEFFREY H · 2010 to 2020
$4.9M
Biorepository of iPSC lines from diverse rat strains for regenerative medicine researchR24OD024622 · OD · MCLEAN HOSPITAL · PI KIM, KWANG-SOO, KONG, SEK WON · 2018 to 2021
$3.4M
NIH HHS R24 OD024622NINDS NIH HHS R01 NS070577
6 · The paper itself

Abstract

Parkinson's disease (PD) is characterized by the selective death of substantia nigra pars compacta (SNpc) dopaminergic neurons and includes both motor and non-motor symptoms. While numerous models exist for the study of typical PD motor deficits, fewer exist for non-motor symptoms. Previous studies have shown that a Pitx3

Indexed as

AphakiaParkinson DiseaseAnimalsDisease Models, AnimalDopamineDopaminergic NeuronsFemaleHomeodomain ProteinsHumansLevodopaMaleMiceMice, Inbred C57BLSubstantia NigraTranscription FactorsDopamineHomeodomain ProteinsLevodopaTranscription Factorsgastrointestinal functioninflammationmotor functionolfactory functionParkinson's diseasePitx3

Identifiers

PMID35636646
PMCPMC9425627

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.