ArticleNature2022
Brain motor and fear circuits regulate leukocytes during acute stress.
Open access · bronzeAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed, 1 pooled it
22.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
136 citing papers in PubMed, 1 synthesis or guideline pooled it, 208 citations in OpenAlex.
- Grief-Related Chest Pain: A Review, Conceptual Analysis, and Integrative Model.Psychophysiology · 2026Pooled it
- Fast and slow gene expression changes in blood following acute social stress.Brain, behavior, & immunity - health · 2026Article
- Balancing inflammation under stress: glucocorticoid regulation of innate immune pathways.Bioscience reports · 2026Review
- Neuro-immune interactions in tumors, immune-related disorders, and infections.Signal transduction and targeted therapy · 2026Review
- Cytotoxic CD4Nature aging · 2026Article
- Temporal coupling of cortisol and immune cell responses in acute psychosocial stress.Brain, behavior, & immunity - health · 2026Article
- A Data-Driven Threshold for Extreme Hyponatremia in the Emergency Department and Its Association With 28-Day Mortality.The Kaohsiung journal of medical sciences · 2026Article
- Ambient Cold Exposure Modulates B-Cell Distribution via Glucocorticoid-CXCR4 Signaling.International journal of molecular sciences · 2026Article
- Modeling the Exposome in Murine Cardiovascular Disease.JACC. Basic to translational science · 2026Review
- Activation of peripheral muscarinic receptors rescues depressive-like behaviors via gut-brain-axis, involving parasympathetic excitation.Acta pharmacologica Sinica · 2026Article
- Altered Neurovascular Coupling Dynamics During Dobutamine-Induced Acute Stress.Brain and behavior · 2026Article
- Cancer-related pain: A bidirectional modulator of cancer progression.Clinical and translational medicine · 2026Review
- Brain-Heart Crosstalk: Unveiling the Neural-Immune Contribution.Neuroscience bulletin · 2026Article
- Stress and the Immune System: Insights From Psychoneuroimmunology.Physiological research · 2026Review
- A brain-lung circuit drives LPS-induced lung injury via sympathetic neutrophil axis.Journal of neuroinflammation · 2026Article
- Aging diminishes thymic output, reduces naive T cells, promotes memory T-cell accumulation, and impairs thymic regeneration.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Differential protein network and biological functions atlas from multi-tissue proteomics in patients with depression.Molecular psychiatry · 2026Article
- Substance abuse and inflammation: consequences beyond the brain.Trends in immunology · 2026Review
- The effects of physical exercise on inflammation-induced maladaptive neuroplasticity in post-traumatic headache.Neuroscience · 2026Review
- Acute stress alleviates type 2 lung inflammation by restricting ILC2s through corticosterone-glucocorticoid receptor signaling.Cellular & molecular immunology · 2026Article
76 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 5 institutions in 2 countries.
Wolfram C PollerCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. wolfram.poller@mssm.edu.ORCID http://orcid.org/0000-0002-4632-5551
Jeffrey DowneyCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Agnes A MooslechnerCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Nargis KhanDepartment of Medicine, McGill University Health Centre, McGill International TB Centre, Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
Long LiNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-1354-8468
Christopher T ChanCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cameron S McAlpineCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Chunliang XuThe Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-4514-8477
Florian KahlesCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Shun HeCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Henrike JanssenCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
John E MindurCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Sumnima SinghCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Máté G KissCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Laura Alonso-HerranzCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Yoshiko IwamotoCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Rainer H KohlerCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6269-6590
Lai Ping WongDepartment of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Kashish ChetalDepartment of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Scott J RussoNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-6470-1805
Ruslan I SadreyevDepartment of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Ralph WeisslederCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0828-4143
Matthias NahrendorfCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Paul S FrenetteThe Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-0862-9922
Maziar DivangahiDepartment of Medicine, McGill University Health Centre, McGill International TB Centre, Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-1254-6110
Filip K SwirskiCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. filip.swirski@mssm.edu.ORCID http://orcid.org/0000-0002-3163-9152
Harvard University · USAllen Institute for Brain Science · USAlbert Einstein College of Medicine · USMcGill University Health Centre · CAMassachusetts General Hospital · US
Funding
Translational imaging and nanomedicine in inflammatory atherosclerosisP01HL131478 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Zahi A. Fayad · 2017 to 2026
$24.3MPROJECT 4: Somatic evolution of the hematopoietic system in cardiovascular diseaseP01HL142494 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Matthias Nahrendorf · 2019 to 2026
$19.5MMacrophages in homeostasis and cardiovascular diseaseR35HL135752 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SWIRSKI, FILIP K · 2017 to 2023
$5.4MInfluence of sleep on the hematopoietic niche and atherosclerosis during agingR01HL158534 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MCALPINE, CAMERON STUART · 2021 to 2025
$2.1MInfluence of sleep on hematopoietic stem cell diversity and clonality in cardiovascular diseaseR00HL151750 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MCALPINE, CAMERON STUART · 2021 to 2023
$747kInfluence of sleep on hematopoietic stem cell diversity and clonality in cardiovascular diseaseK99HL151750 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MCALPINE, CAMERON STUART · 2020 to 2020
$171kNHLBI NIH HHS K99 HL151750NHLBI NIH HHS P01 HL131478NHLBI NIH HHS P01 HL142494NHLBI NIH HHS R00 HL151750NHLBI NIH HHS R01 HL158534NHLBI NIH HHS R35 HL135752
Abstract
The nervous and immune systems are intricately linked
Indexed as
BrainFearLeukocytesMotor NeuronsNeural PathwaysStress, PsychologicalAnimalsBone Marrow CellsChemokinesCOVID-19Disease SusceptibilityGlucocorticoidsHumansLymphocytesLymphoid TissueMiceChemokinesGlucocorticoids
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.