Evidence map›Paper›PMID 35636430›Full record

ArticleVeterinary medicine and science2022

Survey of hepatitis E virus in pork products and pig stools in Nakhon Pathom Province, Thailand.

Narin Thippornchai, Pornsawan Leaungwutiwong, Nathamon Kosoltanapiwat, Cindy Vuong, Kellyan Nguyen, Tamaki Okabayashi, Awapuhi Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary medicine and science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Design and Analysis of Novel HEV Vaccine Variants and Evaluation of Two Selected Candidates in a Porcine Infection Model.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  3. Prevalence ofOne health (Amsterdam, Netherlands) · 2024
    Article
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  5. Review
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Narin ThippornchaiDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Pornsawan LeaungwutiwongDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.ORCID 0000-0001-6215-8290
Nathamon KosoltanapiwatDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.ORCID 0000-0001-7465-0696
Cindy VuongDepartment of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Kellyan NguyenDepartment of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Tamaki OkabayashiDepartment of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Musashimurayama, Japan.
Awapuhi LeeDepartment of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Mahidol University · THUniversity of Hawaiʻi at Mānoa · USUniversity of Miyazaki · JP

Funding

Transdisciplinary Health Disparities Research Training for Native Hawaiians and Pacific StudentsT37MD008636 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI KAHOLOKULA, JOSEPH KEAWE'AIMOKU, SY, ANGELA U · 2014 to 2025
$2.7M
NIMHD NIH HHS T37 MD008636
6 · The paper itself

Abstract

backgroundHepatitis E virus (HEV) is an important public health threat resulting in more than 3 million symptomatic cases and 70,000 deaths annually. HEV is classified into at least eight genotypes, and five are associated with human infection. Genotypes 1 and 2 primarily affect humans, whereas genotypes 3 and 4 circulate in both humans and swine and are considered zoonotic viruses. Previous studies in Central Thailand have reported human HEV isolates with high similarity to swine strains and high seroprevalence in pigs, suggesting the potential for pig-to-human transmission.

objectivesThis study aimed to detect and analyse HEV in pork products and pig stools collected from local markets and pig farms in Nakhon Pathom Province in Central Thailand.

methodsA total of 177 pig stool and 214 pork product samples were detected for HEV by using RT-PCR amplification. Next, nucleotide sequencing and phylogenetic analysis were performed.

resultsWe found one sample of pork products (1/214, 0.5%), which was a pig liver sample (1/51, 2.0%), and 49 HEV-positive samples in pig stools (49/177, 27.7%). Phylogenetic analysis showed that all these HEV sequences belonged to genotype 3, with a high correlation between our samples and HEV from humans and swine was previously reported in Thailand.

conclusionsThis study suggested that the consumption of poorly sanitized or uncooked animal meat or food and frequent exposure to pig stools may be risk factors for HEV infections in humans.

Indexed as

Hepatitis EHepatitis E virusMeat ProductsRed MeatSwine DiseasesAnimalsHumansNucleotidesPhylogenyRNA, ViralSeroepidemiologic StudiesSwineThailandNucleotidesRNA, Viralhepatitis E viruspig stoolspork productsThailand

Identifiers

PMID35636430
PMCPMC9514495
OpenAlexW4281993433

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.