Evidence map›Paper›PMID 35636279›Full record

ReviewSexual medicine2022

Sexual Dysfunction in Infertile Men: A Systematic Review and Meta-Analysis.

Yang Liu, Yuning Wang, Zhuonan Pu, Yuchao Wang, Yixin Zhang, Chuankun Dong, Yan Zeng, Shu Zhou

Open access · goldAbstract readReview
In one paragraph

Review in Sexual medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Erectile Dysfunction and Oxidative Stress: A Narrative Review.International journal of molecular sciences · 2025
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yang LiuCollege of Clinical Medical Sciences, Dalian Medical University, Dalian, China.
Yuning WangCollege of Clinical Medical Sciences, Dalian Medical University, Dalian, China.
Zhuonan PuCollege of Clinical Medical Sciences, Dalian Medical University, Dalian, China.
Yuchao WangCollege of Clinical Medical Sciences, Dalian Medical University, Dalian, China.
Yixin ZhangCollege of Clinical Medical Sciences, Dalian Medical University, Dalian, China.
Chuankun DongCollege of Clinical Medical Sciences, Dalian Medical University, Dalian, China.
Yan ZengCollege of Clinical Medical Sciences, Dalian Medical University, Dalian, China.
Shu ZhouThe First Affiliated Hospital, Dalian Medical University, Dalian, China. Electronic address: zhoushu1000@163.com.
Dalian Medical University · CNFirst Affiliated Hospital of Dalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccording to previous studies of male infertility, we found that the association between sexual dysfunction and male infertility was reported rarely and controversially.

aimWe carried out this 1meta-analysis to evaluate the prevalence of sexual dysfunction and the International Index of Erectile Function (IIEF) score in infertile men.

methodsA systematic search of the target literature was conducted using PubMed, EMBASE, and Cochrane Library. Data were analyzed using Review Manager 5.4 software. Standardized mean differences (SMD) with the corresponding 95% confidence intervals (95% CIs) were implemented in 6 controlled studies as a measure of effect size to assess the relationship between sexual dysfunction and male infertility and Odds Ratio (OR) were performed for the morbidity between infertility group and fertility group. OUTCOMES: Men in infertile group were found with higher prevalence of sexual dysfunction and lower IIEF values than in controls.

resultsA meta-analysis of morbidity was performed in 8 of 10 controlled studies. Meta-analysis of the 8 studies found remarkable higher prevalence of sexual dysfunction in men with infertility than in controls (OR = 2.66, 95% confidence interval = 1.69-4.19, P < .0001; I² = 67%, P for heterogeneity = 0.004). Another meta-analysis of evidence suggested that IIEF in infertile men was lower than controls (SMD = -0.47, 95% confidence interval = -0.63 to -0.31, P < .00001; I² = 64%, p for heterogeneity = 0.02). CLINICAL IMPLICATIONS: We recommend further research based on the relevant criteria of region, sample size, rigorous statistical analysis, and research design. STRENGTHS & LIMITATIONS: This systematic review is the first to evaluate the prevalence of sexual dysfunction and the score of sexual dysfunction in male infertility. Investigation on the topic is scarce, and only few studies used appropriate measures.

conclusionsMale infertility was associated with an increase in the prevalence of sexual dysfunction. The areas most affected by sexual function were erectile function, orgasm and sexual desire. Liu Y, Wang Y, Dong C, et al. Sexual Dysfunction in Infertile Men: A Systematic Review and Meta-Analysis. Sex Med 2022;10:100528.

Indexed as

InfertilityInternational Index of Erectile FunctionMenSexual Dysfunction

Identifiers

PMID35636279
PMCPMC9386642
OpenAlexW4282012022

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.