ArticleSleep medicine2022
Effect of positive airway pressure therapy of obstructive sleep apnea on circulating Angiopoietin-2.
Article in Sleep medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Metabolic assessments of neurostimulation therapy to reduce apnea (MANTRA) trial: rationale and methods.Sleep & breathing = Schlaf & Atmung · 2026Trial
- CPAP may promote an endothelial inflammatory milieu in sleep apnoea after coronary revascularization.EBioMedicine · 2024Trial
- Statins Restore Endothelial Protection against Complement Activity in Obstructive Sleep Apnea: A Randomized Clinical Trial.Annals of the American Thoracic Society · 2023Trial
- Dynamics in Pro-Inflammatory Cytokines in Response to Hypoglossal Nerve Stimulation in Obstructive Sleep Apnea.Laryngoscope investigative otolaryngology · 2026Article
- Heterogeneity of vascular inflammation in obstructive sleep apnea: effects of continuous positive airway pressure therapy.Annals of the American Thoracic Society · 2026Article
- Individualized treatment effects of CPAP on secondary cardiovascular outcomes in non-sleepy obstructive sleep apnea patients.Communications medicine · 2026Article
- TRPC Channels as Mediators of Hypoxia-Induced Pulmonary Hypertension in Obstructive Sleep Apnea.International journal of molecular sciences · 2026Review
- Beyond the apnea-hypopnea index: a call to action for a multidimensional evaluation in obstructive sleep apnea.Frontiers in sleep · 2026Article
- Obstructive Sleep Apnea: An Evolving Therapeutic Landscape with an Emerging Role for Incretin-Based Therapies.Advances in therapy · 2025Review
- Auto-adjusting positive airway pressure: the fine line between engineering and medicine.Sleep & breathing = Schlaf & Atmung · 2025Review
- Obstructive sleep apnea is a risk factor for incident COVID-19 infection.Sleep & breathing = Schlaf & Atmung · 2025Article
- Obstructive Sleep Apnea Endophenotypes.Sleep science (Sao Paulo, Brazil) · 2025Review
- Exploring the Relationship Between Sleep Apnea, Myocardial Infarct Size, and Coronary Collaterals in Acute Myocardial Infarction: A Multidisciplinary Study.Nature and science of sleep · 2025Article
- Response to the Letter regarding the EBIOM-D-23-04056: "CPAP may promote an endothelial inflammatory milieu in sleep apnoea after coronary revascularization".EBioMedicine · 2024Article
- Tackling obstructive sleep apnea with pharmacotherapeutics: expert guidance.Expert opinion on pharmacotherapy · 2024Review
- Positive airway pressure delivery: overcoming old hurdles, exploring new frontiers.Frontiers in sleep · 2024Article
- Reimagining obstructive sleep apnoea: a new era for sleep medicine.The Lancet. Respiratory medicine · 2023Article
- Expression of Angiopoietin-2 in Lung Tissue of Juvenile SD Rats with Lipopolysaccharide-Induced Acute Lung Injury and the Role of Ulinastatin.Archivum immunologiae et therapiae experimentalis · 2023Article
- Advanced Proteomics and Cluster Analysis for Identifying Novel Obstructive Sleep Apnea Subtypes before and after Continuous Positive Airway Pressure Therapy.Annals of the American Thoracic Society · 2023Article
- Obstructive Sleep Apnea and Longitudinal Changes in Interstitial Lung Imaging and Lung Function: The MESA Study.Annals of the American Thoracic Society · 2023Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundObstructive sleep apnea (OSA) has been identified as a possible contributor to interstitial lung disease. While positive airway pressure (PAP) is effective therapy for OSA, it causes large increases in lung volumes during the night that are potentially deleterious, analogous to ventilator-induced lung injury, although this has not been previously studied. The goal of this study was to assess the impact of PAP therapy on four biomarkers of alveolar epithelial and endothelial injury and extracellular matrix remodeling in patients with OSA.
methodsIn 82 patients with moderate to severe OSA who were adherent to PAP therapy, surfactant protein D, osteopontin, angiopoietin-2, and matrix metalloprotease-7 were measured by ELISA in serum samples collected before and 3- to 6-months after initiation of PAP therapy.
resultsAn increase in angiopoietin-2 level of 0.28 ng/mL following PAP therapy was observed (p = 0.007). This finding was replicated in an independent sample of OSA patients. No significant change was detected in surfactant protein D, osteopontin, or matrix metalloprotease-7.
conclusionsThis finding raises concern for a possible adverse impact of PAP therapy on vascular endothelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.