Evidence map›Paper›PMID 35636002›Full record

ReviewCurrent opinion in structural biology2022

Structural mechanisms of inflammasome regulation revealed by cryo-EM studies.

Jianhao Cao, Grady Nash, Liman Zhang

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in structural biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jianhao CaoDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR 97239, USA.
Grady NashDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR 97239, USA.
Liman ZhangDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR 97239, USA. Electronic address: zhanglim@ohsu.edu.
Oregon Health & Science University · US

Funding

Elucidating the Structural Mechanisms of NAIP Receptors in Bacterial Detection and Inflammasome ActivationR01AI165580 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI Liman Zhang · 2022 to 2026
$2.1M
Structural and Mechanistic Elucidation of NAIP/NLRC4 Inflammasomes in Innate ImmunityR00AI137300 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI ZHANG, LIMAN · 2020 to 2021
$550k
NIAID NIH HHS R00 AI137300NIAID NIH HHS R01 AI165580
6 · The paper itself

Abstract

Inflammasomes are cytosolic protein complexes that form in response to pathogen or damage signals and initiate inflammation. Signal transduction in the inflammasome pathway occurs via protein-protein interaction, protein conformational change, and oligomerization. Recent advances in structural biology have provided multiple insights in inflammasome regulation that are both biologically intriguing and therapeutically valuable. In this review, we summarize the current understanding of three most studied inflammasome complexes: the NAIP/NLRC4, NLRP1, and NLRP3 inflammasomes. We discuss the general mechanisms and unique features of their regulation and how investigating these systems may contribute to therapeutic applications.

Indexed as

InflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinCryoelectron MicroscopyCytosolInflammasomesNLR Family, Pyrin Domain-Containing 3 Protein

Identifiers

PMID35636002
PMCPMC9597862
OpenAlexW4281570986

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.