Evidence map›Paper›PMID 35635844›Full record

ArticleMedical physics2022

Patient-derived heterogeneous breast phantoms for advanced dosimetry in mammography and tomosynthesis.

Marco Caballo, Carolina Rabin, Christian Fedon, Alejandro Rodríguez-Ruiz, Oliver Diaz, John M Boone, David R Dance, Ioannis Sechopoulos

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Article in Medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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0cells of the map it votes in
6citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Marco CaballoDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Carolina RabinFacultad de Ciencias, Instituto de Física, Universidad de la República, Montevideo, Uruguay.
Christian FedonDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Alejandro Rodríguez-RuizDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Oliver DiazDepartment of Mathematics and Computer Science, University of Barcelona, Barcelona, Spain.
John M BooneDepartment of Radiology and Biomedical Engineering, University of California Davis Health, Sacramento, California, USA.
David R DanceNational Co-ordinating Centre for the Physics of Mammography (NCCPM), Royal Surrey County Hospital, Department of Physics, University of Surrey, Guildford, UK.
Ioannis SechopoulosDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.

Funding

National Cancer Institute, National Institutes of Health R01CA181171Susan G. Komen Foundation for the Cure IIR13262248
6 · The paper itself

Abstract

backgroundUnderstanding the magnitude and variability of the radiation dose absorbed by the breast fibroglandular tissue during mammography and digital breast tomosynthesis (DBT) is of paramount importance to assess risks versus benefits. Although homogeneous breast models have been proposed and used for decades for this purpose, they do not accurately reflect the actual heterogeneous distribution of the fibroglandular tissue in the breast, leading to biases in the estimation of dose from these modalities. PURPOSE: To develop and validate a method to generate patient-derived, heterogeneous digital breast phantoms for breast dosimetry in mammography and DBT.

methodsThe proposed phantoms were developed starting from patient-based models of compressed breasts, generated for multiple thicknesses and representing the two standard views acquired in mammography and DBT, that is, cranio-caudal (CC) and medio-lateral-oblique (MLO). Internally, the breast phantoms were defined as consisting of an adipose/fibroglandular tissue mixture, with a nonspatially uniform relative concentration. The parenchyma distributions were obtained from a previously described model based on patient breast computed tomography data that underwent simulated compression. Following these distributions, phantoms with any glandular fraction (1%-100%) and breast thickness (12-125 mm) can be generated, for both views. The phantoms were validated, in terms of their accuracy for average normalized glandular dose (D

resultsThe average D

conclusionsThe developed phantoms can be used for dosimetry simulations to improve the accuracy of dose estimates in mammography and DBT.

Indexed as

Breast NeoplasmsMammographyBreastFemaleHumansPhantoms, ImagingRadiometryTomography, X-Ray Computedbreast densitybreast dosimetrydigital breast tomosynthesisdigital phantomsmammography

Identifiers

PMID35635844
PMCPMC9546119

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.