ArticleeLife2022
Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis.
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Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
What it found
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Nutrient-Sensitive Epigenetic Modifiers as Candidate Biomarkers of Metabolic Dysfunction in Obesity: A Nutrigenomic Review.International journal of molecular sciences · 2026Review
- Clonal Hematopoiesis of Indeterminate Potential and Cardiometabolic Disease: Challenges, Controversies and Future Perspectives.International journal of molecular sciences · 2025Review
- Dnmt3a2 expression during embryonic development is required for phenotypic stability.Communications biology · 2025Article
- Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue.Nature genetics · 2025Article
- Dynamic Rendition of Adipose Genes Under Epigenetic Regulation: Revealing New Mechanisms of Obesity Occurrence.Current issues in molecular biology · 2025Review
- 14-3-3ζ allows for adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation.Molecular metabolism · 2025Article
- Epigenetic Mechanisms of Obesity: Insights from Transgenic Animal Models.Life (Basel, Switzerland) · 2025Review
- Tissue-specific roles of de novo DNA methyltransferases.Epigenetics & chromatin · 2025Review
- DNA methylation and demethylation in adipocyte biology: roles of DNMT and TET proteins in metabolic disorders.Frontiers in endocrinology · 2025Review
- Epigenetic Reprogramming and Inheritance of the Cellular Differentiation Status Following Transient Expression of a Nonfunctional Dominant-Negative Retinoblastoma Mutant in Murine Mesenchymal Stem Cells.International journal of molecular sciences · 2024Article
- Key questions and gaps in understanding adipose tissue macrophages and early-life metabolic programming.American journal of physiology. Endocrinology and metabolism · 2024Review
- Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch.Science advances · 2024Article
- Dose-dependent effects of Dnmt3a in an inducible murine model of KrasExperimental hematology · 2024Article
- Article
- Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress.Epigenetics & chromatin · 2024Article
- A negative feedback loop between TET2 and leptin in adipocyte regulates body weight.Nature communications · 2024Article
- Clonal haematopoiesis, ageing and kidney disease.Nature reviews. Nephrology · 2024Review
- Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress.bioRxiv : the preprint server for biology · 2024Article
- DNA Methylation in the Hypothalamic Feeding Center and Obesity.Journal of obesity & metabolic syndrome · 2023Review
- Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits.Cell reports · 2023Article
Corrections and comments
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Authors and funding
18 authors at 2 institutions in 1 country.
Ayala TovyStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.ORCID 0000-0002-3621-6642
Jaime M ReyesStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.ORCID 0000-0001-7895-2472
Linda ZhangStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Yung-Hsin HuangStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Carina RosasStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Alexes C DaquinagInstitute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center, Houston, United States.
Anna GuzmanStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Raghav RamabadranStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Chun-Wei ChenStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Tianpeng GuStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Sinjini GuptaStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Laura OrtinauDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Dongsu ParkDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Aaron R CoxDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Rachel E RauStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Sean M HartigDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.ORCID 0000-0002-2695-2072
Mikhail G KoloninGraduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, United States.
Margaret A GoodellStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.ORCID 0000-0003-1111-2932
Baylor College of Medicine · USThe University of Texas Health Science Center at Houston · US
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MUM1HG006348: Cas9 Genome Integrity Supplemental ProposalUM1HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney, Chih-Wei Logan Hsu · 2016 to 2026
$47.5MWnt signaling in muscle stem cell agingP01AG036695 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMAS A. RANDO · 2011 to 2026
$29.3MConsortium for Broad Based Disease Phenotyping of Knockout MiceU54HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI BEAUDET, ARTHUR L., PAYLOR, RICHARD E · 2011 to 2015
$17.0MREGULATION OF HEMATOPOIETIC PROGENITORS BY DE NOVO DNA METHYLATIONR01DK092883 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2012 to 2024
$7.4MDNMT3A in Development of Hematologic MalignanciesR01CA183252 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MARGARET A. GOODELL · 2014 to 2026
$7.1MNoradrenergic mechanisms in breathing and respiratory pathophysiologiesR01HL130249 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI RAY, RUSSELL S · 2016 to 2024
$5.3MMETABOLIC IMPACTS OF TYPE II INTERFERON SIGNALS IN OBESITYR01DK114356 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI HARTIG, SEAN · 2017 to 2025
$4.6MWNT1 Function in Stem Cells in Osteogenesis Imperfecta and Craniofacial-Skeletal TissuesR01DE031162 · NIDCR · BAYLOR COLLEGE OF MEDICINE · PI LEE, BRENDAN, PARK, DONGSU · 2021 to 2025
$2.9MDefining periosteal skeletal stem cells and novel migration mechanisms in bone regeneration and repair in vivoR01AR072018 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI PARK, DONGSU · 2018 to 2023
$2.1MBD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430kThe role of DNMT3A in gene regulation and stem cell expansionK00CA222736 · NCI · STANFORD UNIVERSITY · PI HUANG, YUNG-HSIN · 2020 to 2023
$379kHoward Hughes Medical InstituteNCI NIH HHS F99 CA222736NCI NIH HHS K00 CA222736NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA183252NCRR NIH HHS S10 RR024574NHGRI NIH HHS U54 HG006348NHGRI NIH HHS UM1 HG006348NHLBI NIH HHS R01 HL130249NIAMS NIH HHS R01 AR072018NIA NIH HHS P01 AG036695NIDCR NIH HHS R01 DE031162NIDDK NIH HHS R01 DK092883NIDDK NIH HHS R01 DK114356NIDDK NIH HHS R56 DK092883Wellcome Trust
Abstract
DNA Methyltransferase 3 A (DNMT3A) is an important facilitator of differentiation of both embryonic and hematopoietic stem cells. Heterozygous germline mutations in
Indexed as
Intellectual DisabilityMetabolism, Inborn ErrorsObesity, MorbidAdipogenesisAnimalsDNADNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AMiceDNADNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AadiposeCpGdevelopmental biologyDNA methylationDNMT3AepigeneticsmouseObesityregenerative medicinestem cells
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