Evidence map›Paper›PMID 35635567›Full record

ArticleEuropean journal of nutrition2022

Inflammatory potential of the diet and association with risk of differentiated thyroid cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

Lucie Lécuyer, Nasser Laouali, Laure Dossus, Nitin Shivappa, James R Hébert, Antonio Agudo, Anne Tjonneland, Jytte Halkjaer, Kim Overvad, Verena A Katzke and 25 more

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In one paragraph

Article in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Dietary Pattern and Risk of Thyroid Cancer: A Systematic Review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 20 institutions in 8 countries.

Lucie LécuyerParis-Saclay University, UVSQ, Gustave Roussy, Inserm, CESP, Team "Exposome and Heredity", 94807, Villejuif, France.
Nasser LaoualiParis-Saclay University, UVSQ, Gustave Roussy, Inserm, CESP, Team "Exposome and Heredity", 94807, Villejuif, France.
Laure DossusSection of Nutrition and Metabolism, International Agency for Research On Cancer, 150, Cours Albert Thomas, 69008, Lyon, France.
Nitin ShivappaCancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA.
James R HébertCancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA.
Antonio AgudoUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Anne TjonnelandDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark.
Jytte HalkjaerDanish Cancer Society Research Center, Institute of Cancer Epidemiology, Copenhagen, Denmark.
Kim OvervadDepartment of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.
Verena A KatzkeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Charlotte Le CornetDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Matthias B SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Franziska JannaschDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
Claudia AgnoliEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
Rosario TuminoHyblean Association for Epidemiological Research, A.I.R.E.-O.N.L.U.S., Ragusa, Italy.
Luca DragnaUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, 10126, Turin, Italy.
Gabriella IannuzzoDipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.
Torill Enget JensenDepartment of Community Medicine, The Arctic University of Norway, Tromsø, Norway.
Magritt BrustadDepartment of Community Medicine, The Arctic University of Norway, Tromsø, Norway.
Guri SkeieDepartment of Community Medicine, The Arctic University of Norway, Tromsø, Norway.
Raul Zamora-RosUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Miguel Rodriguez-BarrancoEscuela Andaluza de Salud Pública (EASP), 18011, Granada, Spain.
Pilar AmianoMinistry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Spain.
María-Dolores ChirlaqueDepartment of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain.
Eva ArdanazCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain.
Martin AlmquistDepartment of Clinical Sciences Lund, Skåne University Hospital, Lund University, Lund, Sweden.
Emily SonestedtDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Maria SandströmDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
Lena Maria NilssonDepartment of Epidemiology and Global Health, Umeå University, Umeå, Sweden.
Elisabete WeiderpassInternational Agency for Research On Cancer, Lyon, France.
Inge HuybrechtsSection of Nutrition and Metabolism, International Agency for Research On Cancer, 150, Cours Albert Thomas, 69008, Lyon, France.
Sabina RinaldiSection of Nutrition and Metabolism, International Agency for Research On Cancer, 150, Cours Albert Thomas, 69008, Lyon, France.
Marie-Christine Boutron-Ruault *Paris-Saclay University, UVSQ, Gustave Roussy, Inserm, CESP, Team "Exposome and Heredity", 94807, Villejuif, France.
Thérèse Truong *Paris-Saclay University, UVSQ, Gustave Roussy, Inserm, CESP, Team "Exposome and Heredity", 94807, Villejuif, France. therese.truong@inserm.fr.ORCID http://orcid.org/0000-0002-2943-6786
Centre international de recherche sur le cancer · FRInserm · FRGerman Cancer Research Center · DEInstitut d'Investigació Biomédica de Bellvitge · ESLund University · SEUiT The Arctic University of Norway · NOUmeå University · SEUniversity of Potsdam · DEUniversity of South Carolina · USAarhus University · DKBasque Government · ESDanish Cancer Society · DKFederico II University Hospital · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITInstituto de Investigación Biosanitaria de Granada · ESInstituto de Salud Pública de Navarra · ESInstituto Murciano de Investigación Biosanitaria · ESNorthern Norway Regional Health Authority · NOPiedmont Reference Center for Epidemiology and Cancer Prevention · ITUniversity of Copenhagen · DK

Funding

Medical Research Council MC_UU_00006/1Medical Research Council MR/M012190/1Medical Research Council MR/N003284/1World Health Organization 001
6 · The paper itself

Abstract

purposeChronic inflammation is thought to initiate or promote differentiated thyroid cancer (DTC) and previous studies have shown that diet can modulate this inflammatory process. We aimed to evaluate the association of several dietary scores reflecting the inflammatory potential of the diet with DTC risk.

methodsWithin the EPIC cohort, 450,063 participants were followed during a mean period of 14 years, and 712 newly incident DTC cases were identified. Associations between four dietary inflammatory scores [the dietary inflammatory index (DII

resultsPositive associations were observed between DTC risk and the DIIs (HR for 1 SD increase in DII: 1.11, 95%CI: 1.01, 1.23, similar results for its derivatives), but not with the ISD (HR for 1 SD increase: 1.04, 95% CI 0.93, 1.16).

conclusionDiet-associated inflammation, as estimated by the DII and its derivatives, was weakly positively associated with DTC risk in a European adult population. These results suggesting that diet-associated inflammation acts in the etiology of DTC need to be validated in independent studies.

Indexed as

AdenocarcinomaThyroid NeoplasmsAdultCohort StudiesDietHumansInflammationProspective StudiesRisk FactorsCohortDietEPICInflammationThyroid cancer

Identifiers

PMID35635567
OpenAlexW4281674872

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.