ArticleeLife2022
Inhibitory control of frontal metastability sets the temporal signature of cognition.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Neural timescales from a computational perspective.Nature neuroscience · 2026Review
- Neuromorphic hierarchical modular reservoirs.Nature communications · 2026Article
- Neurochemical-hemodynamic-electrophysiological coupling in the neonatal brain: a multimodal MRS-fMRI-EEG investigation.Frontiers in neuroscience · 2026Article
- Neurons in auditory cortex integrate information within a constrained and context-invariant temporal window.Current biology : CB · 2025Article
- Neurons in auditory cortex integrate information within constrained temporal windows that are invariant to the stimulus context and information rate.bioRxiv : the preprint server for biology · 2025Article
- Brain-wide organization of intrinsic timescales at single-neuron resolution.bioRxiv : the preprint server for biology · 2025Article
- Development of brain metastable dynamics during the equivalent of the third gestational trimester.Developmental cognitive neuroscience · 2025Review
- Consistent Hierarchies of Single-Neuron Timescales in Mice, Macaques, and Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural timescales reflect behavioral demands in freely moving rhesus macaques.Nature communications · 2024Article
- Neural timescales reflect behavioral demands in freely moving rhesus macaques.bioRxiv : the preprint server for biology · 2023Article
- Article
- Anterior Cingulate Cortex and the Control of Dynamic Behavior in Primates.Current biology : CB · 2020Review
- A Diversity of Intrinsic Timescales Underlie Neural Computations.Frontiers in neural circuits · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortical dynamics are organized over multiple anatomical and temporal scales. The mechanistic origin of the temporal organization and its contribution to cognition remain unknown. Here, we demonstrate the cause of this organization by studying a specific temporal signature (time constant and latency) of neural activity. In monkey frontal areas, recorded during flexible decisions, temporal signatures display specific area-dependent ranges, as well as anatomical and cell-type distributions. Moreover, temporal signatures are functionally adapted to behaviourally relevant timescales. Fine-grained biophysical network models, constrained to account for experimentally observed temporal signatures, reveal that after-hyperpolarization potassium and inhibitory GABA-B conductances critically determine areas' specificity. They mechanistically account for temporal signatures by organizing activity into metastable states, with inhibition controlling state stability and transitions. As predicted by models, state durations non-linearly scale with temporal signatures in monkey, matching behavioural timescales. Thus, local inhibitory-controlled metastability constitutes the dynamical core specifying the temporal organization of cognitive functions in frontal areas.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.