Evidence map›Paper›PMID 35635376›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Activation of cGAS-STING by Lethal Malaria N67C Dictates Immunity and Mortality through Induction of CD11b

Yang Du, Yien Luo, Zhiqiang Hu, Jiansen Lu, Xin Liu, Changsheng Xing, Jian Wu, Tianhao Duan, Junjun Chu, Helen Y Wang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Interaction ofiScience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Yang DuDepartment of Medicine, and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Yien LuoDepartment of Medicine, and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Zhiqiang HuDepartment of Immunology, Guangdong Provincial Key Lab of Single Cell Technology and Application, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Jiansen LuDepartment of Immunology, Guangdong Provincial Key Lab of Single Cell Technology and Application, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Xin LiuDepartment of Medicine, and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Changsheng XingDepartment of Medicine, and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Jian WuMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Tianhao DuanDepartment of Medicine, and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Junjun ChuDepartment of Medicine, and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Helen Y WangDepartment of Medicine, and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Xin-Zhuan SuMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Xiao YuDepartment of Immunology, Guangdong Provincial Key Lab of Single Cell Technology and Application, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Rong-Fu WangDepartment of Medicine, and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
University of Southern California · USHouston Methodist · USChildren's Hospital of Los Angeles · USNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · USSouthern Medical University · CNThird Affiliated Hospital of Southern Medical University · CNXiangya Hospital Central South University · CN

Funding

Transport Oncophysics CoreU54CA210181 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI SHEN, HAIFA · 2016 to 2020
$9.3M
Novel Strategies for Intervention of Inflammatory Diseases and Cancer - Research Supplement to R01-CA101795R01CA101795 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WANG, RONGFU · 2004 to 2022
$4.6M
Division of Intramural Research, National Institute of Allergy and Infectious DiseasesGuangdong Basic and Applied Basic Research Foundation 2019B1515120033Guangdong Basic and Applied Basic Research Foundation 2021A1515012140National Cancer Institute, NIH R01CA101795National Cancer Institute, NIH U54CA210181National Science Foundation of China 81801579National Science Foundation of China 82171741NCI NIH HHS R01 CA101795NCI NIH HHS U54 CA210181NIH HHSScience and Technology Planning Project of Guangzhou 201904010064
6 · The paper itself

Abstract

Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) play critical roles in the innate immunity against infectious diseases and are required to link pathogen DNA sensing to immune responses. However, the mechanisms by which cGAS-STING-induced cytokines suppress the adaptive immune response against malaria infections remain poorly understood. Here, cGAS-STING signaling is identified to play a detrimental role in regulating anti-malaria immunity. cGAS or STING deficiency in mice markedly prolongs mouse survival during lethal malaria Plasmodium yoelii nigeriensis N67C infections by reducing late interleukin (IL)-6 production. Mechanistically, cGAS/STING recruits myeloid differentiation factor 88 (MyD88) and specifically induces the p38-dependent signaling pathway for late IL-6 production, which, in turn, expands CD11b

Indexed as

MalariaMonocytesAnimalsDNAInterleukin-6Membrane ProteinsMiceMyeloid Differentiation Factor 88NucleotidyltransferasesDNAInterleukin-6Membrane ProteinsMyeloid Differentiation Factor 88NucleotidyltransferasesCyclic GMP-AMP synthase /STING signalinginterleukin-6malariaproinflammatory monocytes

Identifiers

PMID35635376
PMCPMC9353503
OpenAlexW4281720950

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.