Evidence map›Paper›PMID 35635321›Full record

ArticleAmerican journal of physiology. Renal physiology2022

NHE3 in the thick ascending limb is required for sustained but not acute furosemide-induced urinary acidification.

Jianxiang Xue, Linto Thomas, Jessica A Dominguez Rieg, Robert A Fenton, Timo Rieg

Open access · goldAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Renal TRPM6 but not Kv1.1 is required for magnesium homeostasis in mice.American journal of physiology. Renal physiology · 2026
    Article
  2. Article
  3. Article
  4. Sex differences in renal acid-base regulation.American journal of physiology. Renal physiology · 2025
    Article
  5. Article
  6. Revisiting voltage-coupled HAmerican journal of physiology. Renal physiology · 2024
    Review
  7. New functions and roles of the NaPflugers Archiv : European journal of physiology · 2024
    Review
  8. Guidelines on antibody use in physiology research.American journal of physiology. Renal physiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jianxiang XueDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.ORCID 0000-0001-8847-0581
Linto ThomasDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.ORCID 0000-0003-3344-1307
Jessica A Dominguez RiegDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Robert A FentonDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0003-1623-199X
Timo RiegDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.ORCID 0000-0001-6082-662X
University of South Florida · USAarhus University · DK

Funding

Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
Coordinating Unit for DiaCompU24DK115255 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2017 to 2020
$11.6M
Role of Renal and Intestinal AC6 and NHE3 for Phosphate HomeostasisR01DK110621 · NIDDK · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI RIEG, TIMO · 2016 to 2020
$1.7M
Pharmacological Npt2a inhibition as a treatment for hyperphosphatemia in chronic kidney diseaseI01BX004968 · VA · JAMES A. HALEY VA MEDICAL CENTER · PI RIEG, TIMO · 2021 to 2024
–
BLRD VA I01 BX004968NIDDK NIH HHS R01 DK110621NIDDK NIH HHS U24 DK076169NIDDK NIH HHS U24 DK115255
6 · The paper itself

Abstract

Na

Indexed as

AlkalosisFurosemideAnimalsHydrogen-Ion ConcentrationMiceSodiumSodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersFurosemideSodiumSodium-Hydrogen Exchanger 3Sodium-Hydrogen Exchangersacid-basefurosemidekidneyNa+/H+ exchanger isoform 3thick ascending limb

Identifiers

PMID35635321
PMCPMC9306792
OpenAlexW4281852905

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.