Evidence map›Paper›PMID 35635320›Full record

ReviewPhysiological reviews2023

Evolution of the diagnostic value of "the sugar of the blood": hitting the sweet spot to identify alterations in glucose dynamics.

Faidon Magkos, Dominic N Reeds, Bettina Mittendorfer

Abstract readReview
In one paragraph

Review in Physiological reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Faidon MagkosDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark.ORCID 0000-0002-1312-7364
Dominic N ReedsCenter for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri.ORCID 0000-0001-8632-9410
Bettina MittendorferCenter for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri.ORCID 0000-0003-0049-2677

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Nada A. Abumrad · 1999 to 2026
$30.2M
Triglycerides, Diabetes and Cardiovascular DiseaseP01HL151328 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 2020 to 2026
$19.6M
Washington University Center for Diabetes Translation Research P30DK092950 · NIDDK · WASHINGTON UNIVERSITY · PI Ross C Brownson, Debra Haire-Joshu · 2011 to 2026
$11.7M
OSA AND GLUCOSE METABOLISMR01DK115400 · NIDDK · WASHINGTON UNIVERSITY · PI MITTENDORFER, BETTINA · 2017 to 2021
$3.8M
Apolipoprotein C3-loading of apolipoprotein B100 lipoproteins and cardiovascular disease in patients with type 1 diabetesR01HL161829 · NHLBI · UNIVERSITY OF WASHINGTON · PI HEINECKE, JAY W · 2022 to 2025
$3.3M
Dissecting the Impact of Dietary Protein on Macrophage mTOR Signaling and AtherosclerosisR01HL159461 · NHLBI · WASHINGTON UNIVERSITY · PI Bettina Mittendorfer, Babak Razani · 2022 to 2026
$3.3M
Animal and plant proteins and glucose metabolismR01DK121560 · NIDDK · WASHINGTON UNIVERSITY · PI KLEIN, SAMUEL, MITTENDORFER, BETTINA · 2019 to 2023
$2.8M
NCATS NIH HHS UL1 TR002345NHLBI NIH HHS P01 HL151328NHLBI NIH HHS R01 HL159461NHLBI NIH HHS R01 HL161829NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30 DK092950NIDDK NIH HHS R01 DK115400NIDDK NIH HHS R01 DK121560
6 · The paper itself

Abstract

In this paper, we provide an overview of the evolution of the definition of hyperglycemia during the past century and the alterations in glucose dynamics that cause fasting and postprandial hyperglycemia. We discuss how extensive mechanistic, physiological research into the factors and pathways that regulate the appearance of glucose in the circulation and its uptake and metabolism by tissues and organs has contributed knowledge that has advanced our understanding of different types of hyperglycemia, namely prediabetes and diabetes and their subtypes (impaired fasting plasma glucose, impaired glucose tolerance, combined impaired fasting plasma glucose, impaired glucose tolerance, type 1 diabetes, type 2 diabetes, gestational diabetes mellitus), their relationships with medical complications, and how to prevent and treat hyperglycemia.

Indexed as

Diabetes Mellitus, Type 2Glucose IntoleranceHyperglycemiaPrediabetic StateBlood GlucoseFemaleGlucoseHumansPregnancySugarsBlood GlucoseGlucoseSugarsdiabeteshyperglycemiaobesityprediabetesβ-cell

Identifiers

PMID35635320
PMCPMC9576168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.